Resistance to antiplatelet treatment: The clinical relevance of platelet function assays
| Autor: | Radovan Stančík, Marketa Ryzí, Miroslav Homza, David Šipula, Jiri Plasek, Jaromir Gumulec |
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| Rok vydání: | 2012 |
| Předmět: |
business.industry
Pharmacology medicine.disease Review article High residual platelet reactivity Aspirin/Clopidogrel resistance Pharmacokinetics Pharmacodynamics Immunology medicine Platelet Clinical significance Platelet activation Endothelial dysfunction business Platelet function assay Cardiology and Cardiovascular Medicine Pharmacogenetics |
| Zdroj: | Cor et Vasa. 54(5):e305-e313 |
| ISSN: | 0010-8650 |
| DOI: | 10.1016/j.crvasa.2012.08.003 |
| Popis: | In cardiology, functional platelet activity is not routinely monitored. Platelet function assays should be able to identify patients with high residual platelet reactivity (HPR). High on-treatment platelet reactivity is apparent risk factor for atherothrombosis, however not the only one. Since there are many contributing factors (platelet activation, endothelial dysfunction, and plaque rupture) influencing atherothrombosis. Antiplatelet treatment is targeted to diminish platelet activation. The unique pharmacodynamics, pharmacokinetics of each agent and the pharmacogenetic profile of the recipient need to be taken into consideration. The aim of this review article is to summarize current knowledge of platelet function monitoring and its usefulness in clinical cardiology. |
| Databáze: | OpenAIRE |
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