Three-dimensional chitin-based scaffolds from Verongida sponges (Demospongiae: Porifera). Part II: Biomimetic potential and applications
| Autor: | René Born, Vasilii V. Bazhenov, Hartmut Worch, Silvia Paasch, Gert Richter, Eric Steck, Peter J. Schupp, Stefano Schiaparelli, Greta R. Patzke, Guilherme Muricy, Heike Meissner, Micha Ilan, Wiltrud Richter, Kurt Kummer, Alexander V. Ereskovsky, José Luis Carballo, Zoran Kljajić, Denis V. Kurek, S. Hunoldt, Hermann Ehrlich, V. Krasokhin, Eike Brunner, Martin Kammer, Giorgio Bavestrello, Vadim Sivkov, Denis V. Vyalikh, Manuel Maldonado, Serguei L. Molodtsov, Valery P. Varlamov |
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| Rok vydání: | 2010 |
| Předmět: |
Scaffold
Molecular Conformation Chitin macromolecular substances Regenerative Medicine Biochemistry Regenerative medicine Chondrocyte Microbiology Extracellular matrix chemistry.chemical_compound Chondrocytes Tissue engineering Biomimetics Structural Biology medicine Animals Humans Molecular Biology Tissue Engineering Tissue Scaffolds biology fungi General Medicine biology.organism_classification Porifera carbohydrates (lipids) Sponge Cartilage medicine.anatomical_structure chemistry Biophysics Biomineralization |
| Zdroj: | International Journal of Biological Macromolecules. 47:141-145 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2010.05.009 |
| Popis: | In order to evaluate the biomedical potential of three-dimensional chitinous scaffolds of poriferan origin, chondrocyte culturing experiments were performed. It was shown for the first time that freshly isolated chondrocytes attached well to the chitin scaffold and synthesized an extracellular matrix similar to that found in other cartilage tissue engineering constructs. Chitin scaffolds also supported deposition of a proteoglycan-rich extracellular matrix of chondrocytes seeded bioconstructs in an in vivo environment. We suggest that chitin sponge scaffolds, apart from the demonstrated biomedical applications, are highly optimized structures for use as filtering systems, templates for biomineralization as well as metallization in order to produce catalysts. |
| Databáze: | OpenAIRE |
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