Formulation of Cannabidiol in Colloidal Lipid Carriers
| Autor: | Frederic Schneider, Knut Baumann, Heike Bunjes, Nadine Monika Francke |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pharmaceutical Science
02 engineering and technology drug localization 030226 pharmacology & pharmacy Soybean oil Analytical Chemistry Suspension (chemistry) cannabidiol Colloid chemistry.chemical_compound Drug Delivery Systems 0302 clinical medicine Phase (matter) Drug Discovery Cannabidiol Emulsion Stability Veröffentlichung der TU Braunschweig Lipid Emulsion Phospholipids Drug Carriers ddc:615 Chemistry 021001 nanoscience & nanotechnology emulsion stability solid lipid nanoparticles surgical procedures operative Chemistry (miscellaneous) Emulsion Molecular Medicine Emulsions colloidal lipid carriers Publikationsfonds der TU Braunschweig 0210 nano-technology Drug Localization lipid emulsion food.ingredient Solid lipid nanoparticles digestive system Article Colloidal Lipid Carriers lcsh:QD241-441 03 medical and health sciences food lcsh:Organic chemistry Solid lipid nanoparticle ddc:6 ddc:61 Particle Size Physical and Theoretical Chemistry Organic Chemistry Trimyristin Water Lipid Droplets digestive system diseases Soybean Oil Chemical engineering Emulsifying Agents Nanoparticles Rapeseed Oil Particle size |
| Zdroj: | Molecules 2021, 26(5), 1469; https://doi.org/10.3390/molecules26051469--Molecules annual : CD-ROM and print archive edition of Molecules, journal of synthetic organic and natural product chemistry--1431-5157--1420-3049 Molecules Volume 26 Issue 5 Molecules, Vol 26, Iss 1469, p 1469 (2021) |
| DOI: | 10.3390/molecules26051469 |
| Popis: | In this study, the general processability of cannabidiol (CBD) in colloidal lipid carriers was investigated. Due to its many pharmacological effects, the pharmaceutical use of this poorly water-soluble drug is currently under intensive research and colloidal lipid emulsions are a well-established formulation option for such lipophilic substances. To obtain a better understanding of the formulability of CBD in lipid emulsions, different aspects of CBD loading and its interaction with the emulsion droplets were investigated. Very high drug loads (> 40% related to lipid content) could be achieved in emulsions of medium chain triglycerides, rapeseed oil, soybean oil and trimyristin. The maximum CBD load depended on the type of lipid matrix. CBD loading increased the particle size and the density of the lipid matrix. The loading capacity of a trimyristin emulsion for CBD was superior to that of a suspension of solid lipid nanoparticles based on trimyristin (69% vs. 30% related to the lipid matrix). In addition to its localization within the lipid core of the emulsion droplets, cannabidiol was associated with the droplet interface to a remarkable extent. According to a stress test, CBD destabilized the emulsions, with phospholipid-stabilized emulsions being more stable than poloxamer-stabilized ones. Furthermore, it was possible to produce emulsions with pure CBD as the dispersed phase, since CBD demonstrated such a pronounced supercooling tendency that it did not recrystallize, even if cooled to −60 °C. |
| Databáze: | OpenAIRE |
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