The oxygen stress index and levels of circulating interleukin-10 and interleukin-6 in patients with chronic heart failure
| Autor: | Juliusz Smielecki, Ewa Deskur-Smielecka, Henryk Wysocki, Andrzej Wykretowicz, Agnieszka Banaszak, Adam Szczepanik, Jaromir Furmaniuk |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Cardiomyopathy
Dilated Male medicine.medical_specialty Heart disease medicine.medical_treatment chemistry.chemical_element Urine Coronary Artery Disease medicine.disease_cause Dinoprost Oxygen Internal medicine medicine Humans Interleukin 6 Aged Heart Failure biology business.industry Interleukin-6 Middle Aged medicine.disease Interleukin-10 Interleukin 10 Oxidative Stress Endocrinology Cytokine chemistry Heart failure biology.protein Female Cardiology and Cardiovascular Medicine business Oxidative stress |
| Zdroj: | International journal of cardiology. 94(2-3) |
| ISSN: | 0167-5273 |
| Popis: | Objectives : We sought to study circulating levels of pro- and anti-inflammatory cytokines together with the oxygen stress index in patients with chronic heart failure (CHF). Background : Patients with CHF exhibit elevated levels of inflammatory and anti-inflammatory cytokines but the relative level of these cytokines with the oxygen stress index have not been reported. Methods : Twenty-two patients with CHF and 10 control subjects were studied. Plasma levels of IL-6 and IL-10 were determined and the oxygen stress index was evaluated by urine 8-iso-PGF2α estimations. Results : Plasma levels of IL-6 and IL-10 in CHF patients were significantly higher than those observed in the control subjects. Patients with more advanced disease (higher NYHA class) showed higher concentrations of IL-10 and IL-6 than those with less serious disease. 8-iso-PGF2α urine concentration (and therefore the oxygen stress index) was significantly higher in patients with CHF in comparison with control subjects. IL-6 plasma levels, but not IL-10 concentrations, correlated significantly with 8-iso-PGF2α levels in urine. Conclusions : Inflammatory and anti-inflammatory cytokine levels, as well as the oxidative stress index, are increased in patients with chronic heart failure. Inflammatory cytokine IL-6, but not anti-inflammatory cytokine Il-10, levels correlated significantly with the oxygen stress index. |
| Databáze: | OpenAIRE |
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