Pharmacokinetics of zonisamide; saturable distribution into human and rat erythrocytes and into rat brain
| Autor: | Seigo Iwakawa, Shinichi Nakayama, Satoshi Takada, Katsuhiko Okumura, Teruyoshi Yokoyama, Kohshi Nishiguchi, Noriaki Ohnishi, Hajime Nakamura, Jiro Yagi |
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| Rok vydání: | 1992 |
| Předmět: |
Drug
Adult Male Erythrocytes media_common.quotation_subject Antiepileptic drug Zonisamide Administration Oral Pharmacology Pharmacokinetics Blood concentration Medicine Distribution (pharmacology) Animals Humans Tissue Distribution Rats Wistar Chromatography High Pressure Liquid media_common business.industry Brain Isoxazoles Serum concentration Rat brain Rats Anticonvulsants business medicine.drug |
| Zdroj: | Journal of pharmacobio-dynamics. 15(8) |
| ISSN: | 0386-846X |
| Popis: | The distribution of zonisamide, a new antiepileptic drug, in erythrocytes and in brain was studied to clarify the factors influencing its distribution in epileptic patients. In both humans and rats, zonisamide was concentrated significantly in erythrocytes in a saturable manner. When the effective concentration of zonisamide in serum was compared with that in blood in nine refractory epileptic patients taking zonisamide chronically, the variation in effective serum concentration was significantly larger than that in blood concentration. In rats, the distribution in the brain also showed saturability. These results suggest that differences in saturable binding to various tissues may contribute to the wide variation that occurs in the effective serum concentration of zonisamide in epileptic patients and that monitoring of the blood concentration of zonisamide may provide useful information for treatment with this drug. |
| Databáze: | OpenAIRE |
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