Event-related potentials and cognitive performance in multiple sclerosis patients with fatigue

Autor: Krzysztof Słotwiński, Mieszko Zagrajek, Ryszard Podemski, Ewa Gruszka, Małgorzata Bilińska, Anna Pokryszko-Dragan
Rok vydání: 2015
Předmět:
Adult
Male
medicine.medical_specialty
Multiple Sclerosis
Adolescent
Luria-Nebraska Neuropsychological Battery
Clinical Neurology
Dermatology
Electroencephalography
Audiology
Luria-Nebraska neuropsychological battery
Severity of Illness Index
Developmental psychology
03 medical and health sciences
Disability Evaluation
Young Adult
0302 clinical medicine
Cognition
Event-related potential
Severity of illness
medicine
Humans
030212 general & internal medicine
Effects of sleep deprivation on cognitive performance
Child
Evoked Potentials
Fatigue
medicine.diagnostic_test
Multiple sclerosis
Neuropsychology
General Medicine
Middle Aged
medicine.disease
Psychiatry and Mental health
Acoustic Stimulation
Female
Original Article
Neurology (clinical)
Psychology
Cognition Disorders
030217 neurology & neurosurgery
Event-related potentials
Zdroj: Neurological Sciences
ISSN: 1590-3478
Popis: The aim of this study was to evaluate event-related potentials (ERP) and cognition in multiple sclerosis (MS) patients with regard to fatigue and disease-related variables. The study comprised 86 MS patients and 40 controls. Fatigue was assessed using the Fatigue Severity Scale (FSS/FSS-5) and the Modified Fatigue Impact Scale (MFIS/MFISmod). N200 and P300 components of auditory ERP were analyzed. Cognition was evaluated by means of Brief Repeatable Battery of Neuropsychological Tests (BRBNT). The results of ERP and BRBNT were compared between non-fatigued, moderately and severely fatigued MS patients and controls. P300 latency was significantly longer in the whole MS group and in the fatigued patients than in the controls. A positive correlation was found between P300 latency and MFIS/MFISmod results, independent from age and MS-related variables. The fatigued patients scored less than non-fatigued ones in tests evaluating memory, visuomotor abilities and attention. Results of these tests correlated significantly with fatigue measures, independently from MS-related variables. Fatigue in MS patients showed significant relationships with impairment within the memory and attention domains. Parameters of auditory ERP, as electrophysiological biomarkers of cognitive performance, were not independently linked to fatigue.
Databáze: OpenAIRE
Externí odkaz: