Depiction of Major Mite Allergens in Severe Allergic Rhinitis with High Mite Perennial Exposure
| Autor: | Fernando Pineda, Miriam Castillo, Paloma Poza-Guedes, Ruperto González-Pérez |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
House dust mite
biology business.industry medicine.medical_treatment lcsh:Surgery Allergic condition lcsh:RD1-811 Immunotherapy lcsh:Otorhinolaryngology medicine.disease_cause Immunoglobulin E biology.organism_classification lcsh:RF1-547 Airborne allergen Allergen medicine.anatomical_structure Immunology medicine biology.protein Mite business Sensitization Original Investigation |
| Zdroj: | Turk Arch Otorhinolaryngol Turkish Archives of Otorhinolaryngology, Vol 58, Iss 3, Pp 155-162 (2020) |
| ISSN: | 2667-7474 2667-7466 |
| DOI: | 10.5152/tao.2020.5365 |
| Popis: | OBJECTIVE: Airway diseases, including allergic rhinitis, are prompted by specific IgE antibodies against airborne allergens and notably those derived from mites. The presented study focused on the specific IgE immediate response to Dermatophagoides pteronyssinus (D. pteronyssinus) mite major allergens and the corresponding pertinence of molecular diagnosis in patients bothered with severe persistent rhinitis. METHODS: Individuals exhibiting confirmed sensitization to D. pteronyssinus along with a clinical diagnosis of coexisting severe allergic rhinitis were included in the study. In vivo investigations encompassed intradermal testing with a battery of standardized allergenic extracts, concurrent with in vitro specific IgE to the crude extract of D. pteronyssinus, and associated individual molecular allergens were assessed. RESULTS: Fifty-five out of 59 subjects showed serodominant IgE responses to the major allergens Der p 1, Der p 2 and Der p 23. Both Der p 2 and Der p 23 reached a prevalence above 80%, while group 10 allergen tropomyosin was scarcely depicted ( |
| Databáze: | OpenAIRE |
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