Interactions of Intestinal Bacteria with Components of the Intestinal Mucus
| Autor: | Mario Jacques, Jean-Félix Sicard, Josée Harel, Guillaume Le Bihan, Philippe Vogeleer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) commensals goblet cells 030106 microbiology Immunology lcsh:QR1-502 Review medicine.disease_cause Microbiology Bacterial Adhesion biofilm lcsh:Microbiology Mice 03 medical and health sciences fluids and secretions mucus medicine microbiota Animals Humans Intestinal Mucosa Intestinal mucus Bacteria Virulence biology Mucin Mucins Biofilm Pathogenic bacteria pathogens biology.organism_classification Commensalism Mucus Gastrointestinal Microbiome Gut Epithelium 030104 developmental biology Infectious Diseases Biofilms microflora |
| Zdroj: | Frontiers in Cellular and Infection Microbiology, Vol 7 (2017) Frontiers in Cellular and Infection Microbiology |
| ISSN: | 2235-2988 |
| DOI: | 10.3389/fcimb.2017.00387/full |
| Popis: | The human gut is colonized by a variety of large amounts of microbes that are collectively called intestinal microbiota. Most of these microbial residents will grow within the mucus layer that overlies the gut epithelium and will act as the first line of defense against both commensal and invading microbes. This mucus is essentially formed by mucins, a family of highly glycosylated protein that are secreted by specialize cells in the gut. In this Review, we examine how commensal members of the microbiota and pathogenic bacteria use mucus to their advantage to promote their growth, develop biofilms and colonize the intestine. We also discuss how mucus-derived components act as nutrient and chemical cues for adaptation and pathogenesis of bacteria and how bacteria can influence the composition of the mucus layer. |
| Databáze: | OpenAIRE |
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