Comparison of the Phenolic Compound Profile and Antioxidant Potential of Achillea atrata L. and Achillea millefolium L
| Autor: | Dietmar R. Kammerer, Otmar Spring, Florian C. Stintzing, Marek Bunse, Peter Lorenz, Lysanne Salomon |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Antioxidant
Achillea DPPH medicine.medical_treatment Ethyl acetate Pharmaceutical Science antioxidant activity Achillea millefolium L 01 natural sciences Antioxidants Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound Phenols lcsh:Organic chemistry Drug Discovery Achillea atrata L medicine Food science Apigenin Physical and Theoretical Chemistry Luteolin Flavonoids Centaureidin Achillea millefolium biology phenolic metabolome Plant Extracts 010405 organic chemistry Communication 010401 analytical chemistry Organic Chemistry Achillea atrata Plant Components Aerial Flavones biology.organism_classification 0104 chemical sciences chemistry Chemistry (miscellaneous) Solvents Molecular Medicine |
| Zdroj: | Molecules, Vol 26, Iss 1530, p 1530 (2021) Molecules |
| ISSN: | 1420-3049 |
| Popis: | In the present study, Achillea atrata L. and A. millefolium L. were compared for the first time with regard to their phenolic compound profile and antioxidant activity by applying the 2,2-diphenyl-picryl hydrazyl radical assay. For this purpose, aerial plant parts were consecutively extracted with solvents of increasing polarity (dichloromethane, n-butanol, ethyl acetate), revealing that the A. atrata ethyl acetate fraction showed the highest antioxidant activity with an IC50 value of 12.2 ± 0.29 µg/mL compared to 17.0 ± 0.26 µg/mL for A. millefolium. Both species revealed the presence of luteolin, apigenin, centaureidin, and nevadensin exclusively in this most polar fraction, which are known as effective 2,2-diphenyl-picryl hydrazyl radical scavengers. The antioxidant capacity of the aforementioned fractions strikingly correlated with their total phenolic contents, which was highest in the ethyl acetate fraction of A. atrata. Characterization of the metabolite profiles of both Achillea species showed only marginal differences in the presence of key compounds, whereas the concentrations of individual compounds appeared to be species-specific. Our results suggest that A. atrata, based on its compound pattern and bioactivity characteristics, has similar qualities for phytotherapy as A. millefolium. |
| Databáze: | OpenAIRE |
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