Percutaneous absorption of 2,6-di-tert-butyl-4-nitrophenol (DBNP) in isolated perfused porcine skin
| Autor: | Kenneth R. Still, Nancy A. Monteiro-Riviere, James D. Brooks, Jim E. Riviere, Alfred O. Inman, Warren W. Jederberg, Robert L. Carpenter |
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| Rok vydání: | 2003 |
| Předmět: |
Antioxidant
Submarine Medicine Swine Microgram medicine.medical_treatment Static Electricity Nitro compound Absorption (skin) Administration Cutaneous Toxicology Antioxidants Absorption Nitrophenols chemistry.chemical_compound Phenols Skin Physiological Phenomena medicine Animals Humans Organic chemistry Porcine skin chemistry.chemical_classification Ethanol Chromatography 4-Nitrophenol General Medicine Military Personnel chemistry Air Pollution Indoor Percutaneous absorption |
| Zdroj: | Toxicology in Vitro. 17:289-292 |
| ISSN: | 0887-2333 |
| Popis: | DBNP (2,6-di-tert-butyl-4-nitrophenol) has been reported as a potential contaminant in submarines. This yellow substance forms when lubrication oil mist containing the antioxidant additive 2,6-di-tert-butylphenol passes through an electrostatic precipitator and is nitrated. Percutaneous absorption of 14C-DBNP was assessed in the isolated perfused porcine skin flap (IPPSF). Four treatments were studied (n=4 flaps/treatment): 40.0 microgram/cm(2) in 100% ethanol; 40.0 microgram/cm(2) in 85% ethanol/15% H(2)O; 4.0 microgram/cm(2) in 100% ethanol; and 4.0 microgram/cm(2) in 85% ethanol/15% water. DBNP absorption was minimal across all treatment groups, with the highest absorption detected being only 1.08% applied dose in an aqueous ethanol group. The highest mass of 14C-DBNP absorbed was only 0.5 microgram. The majority of the applied dose remained on the surface of the skin. This suggests that there is minimal dermal exposure of DBNP when exposed topically to skin. |
| Databáze: | OpenAIRE |
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