Absorption of Sodium Bisulfite from Peritoneal Dialysis Solutions
| Autor: | Sami F. Halaby, Albert M. Mattocks |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
Urinary system
medicine.medical_treatment Pharmaceutical Science Absorption (skin) Toxicology Absorption Peritoneal dialysis chemistry.chemical_compound Peritoneum Renal Dialysis medicine Animals Sulfites Pharmacology Chromatography Research Solutions Bisulfite medicine.anatomical_structure Biochemistry chemistry Sodium bisulfite Toxicity Rabbits Dialysis (biochemistry) Dialysis Peritoneal Dialysis |
| Zdroj: | Journal of Pharmaceutical Sciences. 54:52-55 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.2600540112 |
| Popis: | Toxic symptoms have been observed in using peritoneal dialysis fluids containing 7 per cent dextrose. The one ingredient suspected as a possible cause of toxicity is sodium bisulfite, present in concentrations of 500mg./L. On reviewing the literature it was obvious that in the quantities this fluid may be used—as much as 10–12L. per day—the amount of bisulfite would be dangerous if appreciable absorption occurs from the dialysis fluid. Five rabbits were injected intraperitoneally with the dialysis fluid containing a portion of the bisulfite labeled with S 35 . Blood levels and urinary excretions were measured, and tissue distribution was evaluated. Rapid absorption occurs from the peritoneum, and the ability of the organism to remove the bisulfite via oxidation or urinary excretion is lost as the blood levels are increased. Thus, the conclusion is that the use of 500mg./L. of sodium bisulfite in peritoneal dialysis fluids is dangerous and should be discontinued. |
| Databáze: | OpenAIRE |
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