Validating prediction scales of type 2 diabetes mellitus in Spain: the SPREDIA-2 population-based prospective cohort study protocol
| Autor: | Miguel Ángel, Salinero-Fort, Carmen, de Burgos-Lunar, José, Mostaza Prieto, Carlos, Lahoz Rallo, Juan Carlos, Abánades-Herranz, Paloma, Gómez-Campelo, Fernando, Laguna Cuesta, Eva, Estirado De Cabo, Francisca, García Iglesias, Teresa, González Alegre, Belén, Fernández Puntero, Luis, Montesano Sánchez, David, Vicent López, Víctor, Cornejo Del Río, Pedro J, Fernández García, Concesa, Sabín Rodríguez, Silvia, López López, Pedro, Patrón Barandío, Margarita Ruiz, Pacheco |
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| Rok vydání: | 2015 |
| Předmět: |
Gerontology
Blood Glucose Male medicine.medical_specialty endocrine system diseases Population Logistic regression Likelihood ratios in diagnostic testing Prediabetic State Bias Risk Factors Epidemiology medicine Protocol Humans Mass Screening EPIDEMIOLOGY Prediabetes Prospective Studies Prospective cohort study education Mass screening Aged education.field_of_study business.industry DIABETES & ENDOCRINOLOGY nutritional and metabolic diseases General Medicine Glucose Tolerance Test Middle Aged medicine.disease Early Diagnosis Logistic Models Diabetes Mellitus Type 2 ROC Curve Sample size determination Spain Emergency medicine Female Public Health PUBLIC HEALTH business |
| Zdroj: | BMJ Open Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid |
| ISSN: | 2044-6055 |
| Popis: | Introduction The incidence of type 2 diabetes mellitus (T2DM) is increasing worldwide. When diagnosed, many patients already have organ damage or advance subclinical atherosclerosis. An early diagnosis could allow the implementation of lifestyle changes and treatment options aimed at delaying the progression of the disease and to avoid cardiovascular complications. Different scores for identifying undiagnosed diabetes have been reported, however, their performance in populations of southern Europe has not been sufficiently evaluated. The main objectives of our study are: to evaluate the screening performance and cut-off points of the main scores that identify the risk of undiagnosed T2DM and prediabetes in a Spanish population, and to develop and validate our own predictive models of undiagnosed T2DM (screening model), and future T2DM (prediction risk model) after 5-year follow-up. As a secondary objective, we will evaluate the atherosclerotic burden of the population with undiagnosed T2DM. Methods and analysis Population-based prospective cohort study with baseline screening, to evaluate the performance of the FINDRISC, DANISH, DESIR, ARIC and QDScore, against the gold standard tests: Fasting plasma glucose, oral glucose tolerance and/or HbA1c. The sample size will include 1352 participants between the ages of 45 and 74 years. Analysis: sensitivity, specificity, positive predictive value, negative predictive value, likelihood ratio positive, likelihood ratio negative and receiver operating characteristic curves and area under curve. Binary logistic regression for the first 700 individuals (derivation) and last 652 (validation) will be performed. All analyses will be calculated with their 95% CI; statistical significance will be p |
| Databáze: | OpenAIRE |
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