Organoselenides as potential immunostimulants and inducers of interferon gamma and other cytokines in human peripheral blood leukocytes
| Autor: | Piasecki E, Ludwik Syper, Jacek Młochowski, Anna D. Inglot, Zielińska-Jenczylik J |
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| Rok vydání: | 1990 |
| Předmět: |
Azoles
Interferon Inducers Chemical Phenomena medicine.medical_treatment Isoindoles Pharmacology Biology Antiviral Agents Blood cell Interferon-gamma Selenium Structure-Activity Relationship Cellular and Molecular Neuroscience chemistry.chemical_compound Adjuvants Immunologic Organoselenium Compounds Leukocytes Organometallic Compounds medicine Humans Immunologic Factors Interferon gamma Phytohemagglutinins Biological response modifiers Molecular Biology Cells Cultured Interferon inducer Dose-Response Relationship Drug Tumor Necrosis Factor-alpha Cell growth Ebselen Drug Synergism Cell Biology Stimulation Chemical Chemistry medicine.anatomical_structure Cytokine chemistry Immunology Molecular Medicine Tumor necrosis factor alpha medicine.drug |
| Zdroj: | Experientia. 46:308-311 |
| ISSN: | 1420-9071 0014-4754 |
| Popis: | A number of organoselenium compounds have been described as anti-inflammatory, antioxidant, glutathione peroxidase-like agents and inhibitors of prostaglandin synthesis. Here we report that bis [2-(N-phenyl-carboxamido)]phenyl diselenide, 2-phenyl-1,2-benzisoselenazol-3(2H)-one (Ebselen) and related compounds are inducers of interferon gamma (IFN-gamma) and tumor necrosis factor (TNF) in human peripheral blood leukocytes. The IFN and TNF response was rapid, occurring within 20 h, and high--up to 1000 and 2000 units ml-1--and was clearly related to the dosage and the structure of the compounds. The action of the compounds and phytohemagglutinin was synergistic. The IFN gamma and TNF production was reduced after removing adherent cells. Although the mode of action of the compounds is not known, they appear to interact directly or indirectly with both adherent and non-adherent leukocytes, and stimulate the synthesis of a set of different cytokines including factors controlling the cell proliferation. Therefore, organoselenides may be regarded as the biological response modifiers. |
| Databáze: | OpenAIRE |
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