Comparison of Ultrasound-Accelerated versus Pigtail Catheter–Directed Thrombolysis for the Treatment of Acute Massive and Submassive Pulmonary Embolism
| Autor: | Omar Z. Chohan, D.J. Agriantonis, G. Kimbiris, D. Leung, Mandip Gakhal, A. Graif, C Fedele, C. Grilli, Ansar Z Vance |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Ultrasonic Therapy medicine.medical_treatment 030204 cardiovascular system & hematology Radiography Interventional Severity of Illness Index Tissue plasminogen activator 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Risk Factors medicine.artery Severity of illness medicine Humans Thrombolytic Therapy Radiology Nuclear Medicine and imaging Retrospective Studies medicine.diagnostic_test business.industry Ultrasound Angiography Digital Subtraction Retrospective cohort study Thrombolysis Middle Aged medicine.disease Surgery Pulmonary embolism Treatment Outcome Anesthesia Angiography Pulmonary artery Female Pulmonary Embolism Tomography X-Ray Computed Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of Vascular and Interventional Radiology. 28:1339-1347 |
| ISSN: | 1051-0443 |
| DOI: | 10.1016/j.jvir.2017.07.004 |
| Popis: | To compare the technical and clinical effectiveness of ultrasound-accelerated endovascular thrombolysis (USAT) versus pigtail catheter-directed thrombolysis (PCDT) for the treatment of acute pulmonary embolism (PE).A single-center retrospective study of patients treated with USAT or PCDT for acute massive or submassive PE between January 2010 and December 2016 was performed by reviewing electronic medical records. Sixty treatments were reviewed (mean patient age, 56.7 y ± 14.6), including 52 cases of submassive PE (21 treated with USAT, 31 with PCDT) and 8 cases of massive PE (3 treated with USAT, 5 with PCDT). Endpoints included pulmonary artery pressure (PAP), Miller PE severity index, tissue plasminogen activator (TPA) dose, infusion duration, procedural variables, and complications.Demographics, PE severity, and right:left ventricular diameter ratios were similar between groups. USAT and PCDT significantly reduced mean PAP (reductions of 7.4 mm Hg [P = .002] and 8.2 mm Hg [P.001], respectively) and Miller index scores (reductions of 45.8% [P.001] and 53% [P.001], respectively) with similar effectiveness (P = .47 and P = .15, respectively). Procedure (P.001) and fluoroscopy (P = .001) times were significantly longer in the USAT group. The USAT group underwent fewer sessions (2.2 ± 0.6 vs 2.4 ± 0.6; P = .17) with shorter infusion times (23.9 h ± 8.8 vs 30.4 h ± 12.6; P = .065) and a lower total dose of TPA (27.1 mg ± 11.3 vs 30.4 mg ± 12.6; P = .075) compared with the PCDT group, but the differences were not significant. Complications (P = .07) and 30-day mortality rates (P = .56) were not significantly different between groups.USAT and PCDT demonstrated comparable effectiveness and safety in the treatment of patients with acute PE. |
| Databáze: | OpenAIRE |
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