The Influence of Alcohol Consumption in Conjunction with Sex Hormone Deficiency on Ca/P Ratio in Rats
| Autor: | Rosilene Fernandes da Rocha, Karina Bortolin Lodi, Ana Maria do Espírito Santo, Adriana Mathias Pereira da Silva Marchini, Sigmar de Mello Rode, Leonardo Marchini |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Universidade de São Paulo (USP), Laboratory of Biomedical Vibrational Spectroscopy, University of Iowa College of Dentistry and Dental Clinics |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Article Subject Endocrinology Diabetes and Metabolism Osteoporosis chemistry.chemical_element 030209 endocrinology & metabolism Alcohol Calcium lcsh:Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Sex hormone-binding globulin Internal medicine medicine Femur lcsh:RC648-665 biology Endocrine and Autonomic Systems business.industry 030206 dentistry medicine.disease chemistry Ovariectomized rat biology.protein business Alcohol consumption Research Article Hormone |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP International Journal of Endocrinology, Vol 2016 (2016) International Journal of Endocrinology |
| ISSN: | 1687-8345 1687-8337 |
| DOI: | 10.1155/2016/3797139 |
| Popis: | Made available in DSpace on 2018-12-11T17:27:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-01-01 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Deficiency of sex hormones and excessive alcohol consumption are factors that have been related to alterations in the pattern of bone mineralization and osteoporosis. The aim of this study was to evaluate possible alterations in the calcium/phosphorus (Ca/P) ratio in the femur of rats subjected to sex hormone deficiency and/or alcohol consumption. Methods. Female and male Wistar rats (n=108) were divided into ovariectomized (Ovx), orchiectomized (Orx), or sham-operated groups and subdivided according to diet: alcoholic diet (20% alcohol solution), isocaloric diet, and ad libitum diet. The diets were administered for 8 weeks. The Ca/P ratio in the femur was analyzed by energy dispersive micro-X-ray spectrometer (EDX). Results. Consumption of alcohol reduced the Ca/P ratio in both females and males. The isocaloric diet reduced the Ca/P ratio in females. In groups with the ad libitum diet, the deficiency of sex hormones did not change the Ca/P ratio in females or males. However, the combination of sex hormone deficiency and alcoholic diet presented the lowest values for the Ca/P ratio in both females and males. Conclusions. There was a reduced Ca/P ratio in the femur of rats that consumed alcohol, which was exacerbated when combined with a deficiency of sex hormones. Institute of Science and Technology Department of Biosciences and Diagnostics Universidade Estadual Paulista (UNESP), Avenida Engenheiro Francisco José Longo 777 Institute of Environmental Science Chemical and Pharmaceutical Department of Mathematical and Earth Sciences Federal University of São Paulo (UNIFESP), Rua Prof. Artur Riedel 275 Institute of Research and Development University of Vale Do Paraíba (UNIVAP) Laboratory of Biomedical Vibrational Spectroscopy, Avenida Shishima Hifumi 2911 Institute of Science and Technology Department of Dental Materials and Prosthesis Universidade Estadual Paulista (UNESP), Avenida Engenheiro Francisco José Longo 777 Department of Preventive and Community Dentistry University of Iowa College of Dentistry and Dental Clinics, N337-1 Dental Science N Institute of Science and Technology Department of Biosciences and Diagnostics Universidade Estadual Paulista (UNESP), Avenida Engenheiro Francisco José Longo 777 Institute of Science and Technology Department of Dental Materials and Prosthesis Universidade Estadual Paulista (UNESP), Avenida Engenheiro Francisco José Longo 777 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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