The National Institute on Aging-Alzheimer’s Association research criteria for mild cognitive impairment due to Alzheimer’s disease: predicting the outcome

Autor: Panagiotis Alexopoulos, Stefan Wagenpfeil, Robert Perneczky, Alexander Kurz, Liang-Hao Guo, Tamara Eisele
Rok vydání: 2012
Předmět:
Male
medicine.medical_specialty
Genotype
MEDLINE
Disease
Neuropsychological Tests
behavioral disciplines and activities
Apolipoproteins E
Neuroimaging
Alzheimer Disease
Internal medicine
mental disorders
Image Processing
Computer-Assisted
National Institute on Aging (U.S.)
medicine
Humans
Dementia
Cognitive Dysfunction
Pharmacology (medical)
Psychiatry
Biological Psychiatry
Survival analysis
Aged
Aged
80 and over
Proportional hazards model
General Medicine
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Survival Analysis
United States
nervous system diseases
Psychiatry and Mental health
Clinical research
Data Interpretation
Statistical
Positron-Emission Tomography
Relative risk
Disease Progression
Regression Analysis
Female
Psychology
human activities
Biomarkers
Follow-Up Studies
Forecasting
Zdroj: European Archives of Psychiatry and Clinical Neuroscience. 263:325-333
ISSN: 1433-8491
0940-1334
DOI: 10.1007/s00406-012-0349-0
Popis: The National Institute on Aging-Alzheimer's Association (NIA-AA) clinical research criteria for mild cognitive impairment (MCI) due to Alzheimer's disease (AD) incorporate the use of biomarkers to classify patients according to the likelihood of the presence of AD pathology. The aim of the study was to compare the risk of progression to AD dementia between the four NIA-AA MCI subgroups using data from the AD Neuroimaging Initiative. Patients with MCI were categorised according to the NIA-AA criteria into subgroups with high, intermediate, and low likelihood of the presence of AD pathology (MCI-high, MCI-intermediate, and MCI-unlikely, respectively) or into a group of patients that only met the MCI-core clinical criteria (MCI-core). Data of follow-up visits conducted 6-60 months after baseline were used to compare the relative risk of future AD dementia between the four subgroups employing a Cox regression model. The MCI-high subgroup (N = 22) had a 2.3 times higher risk of developing AD dementia compared with the MCI-core subgroup (N = 327; P = 0.002), while there was a trend for a higher risk in the MCI-high subgroup in contrast to the MCI-intermediate subgroup (N = 31, P = 0.08). No patients in the MCI-unlikely subgroup (N = 17) progressed to AD dementia. Patients with MCI-high have a higher risk for developing AD dementia. The new NIA-AA MCI criteria represent a valuable research instrument that could be incorporated into the diagnostic process of the MCI syndrome after optimisation and refinement.
Databáze: OpenAIRE
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