Effectiveness of intrauterine treatment with cephapirin in dairy cows with purulent vaginal discharge
| Autor: | L. DesCôteaux, N. Tison, Réjean Lefebvre, Émile Bouchard |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Vaginal discharge
medicine.medical_specialty Vaginoscopy 040301 veterinary sciences medicine.medical_treatment Cattle Diseases Insemination 0403 veterinary science Food Animals medicine Animals Small Animals Gynecology Uterine Diseases Pregnancy Cephapirin Equine business.industry Artificial insemination Uterus 0402 animal and dairy science 04 agricultural and veterinary sciences medicine.disease 040201 dairy & animal science Anti-Bacterial Agents medicine.anatomical_structure Vaginal Discharge Vagina Animal Science and Zoology Cattle Female Endometritis medicine.symptom business |
| Zdroj: | Theriogenology. 89 |
| ISSN: | 1879-3231 |
| Popis: | The objective of this study was to assess the efficacy of cephapirin intrauterine treatment preceding a timed artificial insemination protocol in lactating dairy cows with purulent vaginal discharges (PVDs). Holstein dairy cows (n = 1247) from 18 herds were enrolled in a controlled randomized clinical trial. At 34 days in milk (DIM; ±7 days), cows had a genital examination (transrectal palpation, vaginoscopy, and uterine bacteriology). They were randomly assigned to either the control group (CONT, no treatment) or the treatment group (CEPH) consisting of 1 intrauterine infusion of 500-mg cephapirin benzathine (RCL) (Metricure, Merck Animal Health, Montreal, Canada) regardless of the uterine health status. All cows were systematically enrolled in a presynch-ovsynch protocol for the first insemination. A second genital examination was made 2 weeks later. Cows that received any systemic or local antibiotics 10 days prior sampling to the end of the synchronization protocol were excluded from the study. Reproductive data of cows were collected for at least 300 DIM, entered in a databank, and validated (health record management software, DSAHR). Pregnancy diagnosis was done by transrectal palpation at the routinely scheduled veterinarian visits. On the basis of the highest sum of sensibility and specificity for pregnancy status at 120 DIM, the optimal cutoff for vaginal discharge score was determined as the presence of cloudy discharge with or without purulent material (PVD+, score 2). With a prevalence of 21.6% at 34 DIM, PVD+ was detrimental to the first-service conception rate (FSCR; PVD+: 26 ± 5%; PVD-: 40 ± 3%; P = 0.02). The negative effect of PVD+ was indicated by a hazard ratio of 0.72 (chi-square = 8.58; P |
| Databáze: | OpenAIRE |
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