Retrospective Analysis of Posaconazole Suspension Dosing Strategies in a Pediatric Oncology Population: Single-Center Experience

Autor:	Meier Hsu, Susan K. Seo, Nina Cohen, Sherry Mathew, Jennifer Thackray, Michelle L Kussin, Brian Seyboth, Dazhi Liu, Melissa Pozotrigo, Shirley Qiong Yan
Rok vydání:	2017
Předmět:	Male 0301 basic medicine medicine.medical_specialty Posaconazole Antifungal Agents Adolescent Initial dose 030106 microbiology Population Urology Single Center Electronic Articles Drug Administration Schedule 03 medical and health sciences 0302 clinical medicine Suspensions Neoplasms Retrospective analysis medicine Pediatric oncology Humans 030212 general & internal medicine Dosing Child education Retrospective Studies education.field_of_study business.industry General Medicine Triazoles Surgery Infectious Diseases Child Preschool Pediatrics Perinatology and Child Health Plasma concentration Female business medicine.drug
Zdroj:	Journal of the Pediatric Infectious Diseases Society. 6:e149-e151
ISSN:	2048-7207 2048-7193
DOI:	10.1093/jpids/pix058
Popis:	Limited data on optimal posaconazole dosing strategies for pediatric patients exist. In this study, we found that the median initial dose in patients who achieved a posaconazole plasma concentration of 0.7 μg/mL was 22.8 mg/kg per day whereas the median initial dose in those who did not reach the target concentration was 15.8 mg/kg per day; this result suggests that higher initial doses might be warranted.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723c3704f14907fb4cc38314426aec24 https://doi.org/10.1093/jpids/pix058 Zobrazit plný text záznamu Plný text ve formátu PDF