Transcriptomic changes in pancreatic islets, adipose and liver after Roux-en-Y gastric bypass in a diet-induced obese rat model
| Autor: | Marisa Fernández Cachón, Chen Zhang, Thorsten Schmidt, Lise Christine Biehl Rudkjær, Kristoffer T.G. Rigbolt, Stefan Theis, Jacob Jelsing, Niels Vrang, Mechthilde Falkenhahn |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Physiology Gastric Bypass Adipose tissue 030209 endocrinology & metabolism Inflammation Biology Diet High-Fat Biochemistry Transcriptome Rats Sprague-Dawley 03 medical and health sciences Cellular and Molecular Neuroscience Islets of Langerhans 0302 clinical medicine Endocrinology Weight loss Internal medicine Gene expression Weight Loss medicine Animals Humans Obesity Pancreatic islets nutritional and metabolic diseases Metabolism Obesity Morbid Rats Disease Models Animal medicine.anatomical_structure Adipose Tissue Liver medicine.symptom Insulin Resistance Diet-induced obese 030217 neurology & neurosurgery |
| Zdroj: | Peptides. 136 |
| ISSN: | 1873-5169 |
| Popis: | Roux-en-Y gastric bypass (RYGB) is the most efficient intervention in morbid obesity and promotes metabolic improvements in several peripheral tissues. However, the underlying molecular mechanisms are still poorly understood. To further understand the effects of RYGB on peripheral tissues transcriptomes, we determined transcriptome signatures in pancreatic islets, adipose and liver tissue from diet-induced obese (DIO) rats model following RYGB. Whereas RYGB led to discrete gene expression changes in pancreatic islets, substantial transcriptome changes were observed in metabolic and immune signaling pathways in adipose tissue and the liver, indicating major gene adaptive responses in fat-storing tissues. Compared to RYGB DIO rats, peripheral tissue transcriptome signatures were markedly different in caloric restricted weight matching DIO rats, implying that caloric restriction paradigms do not reflect transcriptomic regulations of RYGB induced weight loss. The present gene expression study may serve as a basis for further investigations into molecular regulatory effects in peripheral tissues following RYGB-induced weight loss. |
| Databáze: | OpenAIRE |
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