A man with immunoglobulin A nephropathy complicated by infection-related glomerulonephritis with glomerular depositions of nephritis-associated plasmin receptor
| Autor: | Kensuke Mitsumoto, Takashi Oda, Rinko Katsunuma, Takafumi Shingu, Aya Mizumoto, Takashi Uzu, Ayano Onishi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Nephrology
Immunoglobulin A Adult Male medicine.medical_specialty Pathology Receptors Peptide Glomerular deposits Kidney Glomerulus 030232 urology & nephrology Case Report 030204 cardiovascular system & hematology urologic and male genital diseases 03 medical and health sciences 0302 clinical medicine Heavy proteinuria Internal medicine medicine Humans medicine.diagnostic_test biology business.industry Acute kidney injury Glomerulonephritis Glomerulonephritis IGA General Medicine medicine.disease biology.protein Renal biopsy business Nephritis |
| Zdroj: | CEN Case Rep |
| Popis: | A 27-year-old man who developed heavy proteinuria with hematuria and acute kidney injury 2 weeks after a fever was referred to our hospital. Because he had low complements without autoantibodies, we clinically diagnosed him with infection-related glomerulonephritis. The proliferation of mesangial cells and endothelial cells with glomerular deposits of immunoglobulin A and complement 3 was found. Deposition of glomerular nephritis-associated plasmin receptor, a marker of infection-related glomerulonephritis, was also found. In addition, the distribution of nephritis-associated plasmin receptor deposition almost perfectly matched the plasmin activity-positive region. Over 3 months later, his symptoms were resolved, although moderate proteinuria and active urine sediment were persistent. He underwent a second renal biopsy, and the histological findings revealed that he had immunoglobulin A nephropathy. Therefore, we diagnosed him with infection-related glomerulonephritis superimposed on immunoglobulin A nephropathy at the first renal biopsy. The glomerular deposition of nephritis-associated plasmin receptor is a useful marker and may cause worsening urinalysis findings after bacterial infection in cases of chronic glomerulonephritis. |
| Databáze: | OpenAIRE |
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