Seroreactivity to human papillomavirus type 16 virus-like particles is lower in high-risk men than in high-risk women
| Autor: | Nancy L. Hubbert, Douglas R. Lowy, Edith I. Svare, John T. Schiller, Chris J.L.M. Meijer, Bernadete Nonnenmacher, Rene B. Christensen, Harald Moi, Adriaan J. C. van den Brule, A. M. Worm, Jan M. M. Walboomers, Susanne K. Kjaer |
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| Předmět: |
Adult
Male Sexually transmitted disease medicine.medical_specialty Adolescent Denmark Sexual Behavior Greenland Sexually Transmitted Diseases Antibodies Viral Danish Sex Factors Risk Factors Seroepidemiologic Studies Epidemiology medicine Humans Immunology and Allergy Sex organ Syphilis Papillomaviridae business.industry Papillomavirus Infections virus diseases Middle Aged medicine.disease female genital diseases and pregnancy complications language.human_language Tumor Virus Infections Sexual Partners Infectious Diseases DNA Viral Immunology language Educational Status Biomarker (medicine) Female Viral disease business Demography |
| Zdroj: | Europe PubMed Central |
| Popis: | Seroreactivity to human papillomavirus type 16 (HPV-16) virus-like particles (VLPs) in men attending clinics for sexually transmitted diseases (STDs) in Denmark (n = 219) and Greenland (n = 88) was compared with seroreactivity in women attending the same clinics and was furthermore related to epidemiologic variables and concurrent HPV DNA detection. Risk factors for male seropositivity in Denmark were lifetime number of sex partners, a history of STDs, and sexual preference and in Greenland were ever having had syphilis and years at school. Although men reported significantly more sex partners, the mean seroreactivity was significantly lower in men than in women: 0.50 and 0.75, respectively, in Denmark and 0.53 and 0.86 in Greenland (P = .0001). Male seropositivity was not correlated with concurrent HPV DNA detection, but only 15 Danish and 6 Greenlandic men had HPV-16 DNA. Presence of HPV-16 VLP antibodies appears to be a biomarker for exposure to genital HPVs in men but is less sensitive than in women. |
| Databáze: | OpenAIRE |
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