Characteristics and outcomes of HIV-1–infected patients with acute respiratory distress syndrome
| Autor: | Joel Andrews, Sushma K. Cribbs, Freny J. Nirappil, Greg S. Martin, Ana Maheshwari, Annette M. Esper |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty ARDS Critical Illness Human immunodeficiency virus (HIV) HIV Infections Comorbidity Acute respiratory distress Critical Care and Intensive Care Medicine medicine.disease_cause Article Pulmonary Disease Chronic Obstructive Risk Factors Antiretroviral Therapy Highly Active Internal medicine Clinical endpoint Humans Medicine Hospital Mortality Prospective Studies Intensive care medicine Prospective cohort study APACHE Asthma Cross Infection Respiratory Distress Syndrome business.industry Age Factors Pneumonia Middle Aged medicine.disease Acute Disease HIV-1 Female business |
| Zdroj: | Journal of Critical Care. 30:60-64 |
| ISSN: | 0883-9441 |
| DOI: | 10.1016/j.jcrc.2014.10.020 |
| Popis: | We determined the prevalence of risk factors for the development of acute respiratory distress syndrome (ARDS), outcomes of critical illness, and the impact of highly active antiretroviral therapy in HIV-1-infected patients. We hypothesized that in an urban county hospital, HIV-1-infected patients with ARDS would have a higher mortality than their HIV-1-uninfected counterparts.Subjects were enrolled between 2006 and 2012. Baseline patient demographics, comorbidities, illness severity, causes of ARDS, and clinical outcomes were obtained. The primary end point was hospital mortality.A total of 178 subjects with ARDS were enrolled in the study; 40 (22%) were infected with HIV-1. The median CD4 count was 75 (15.3-198.3), and 25% were on highly active antiretroviral therapy. HIV-1-infected subjects were significantly younger (44 vs 52 years; P.01) and had higher rates of asthma, chronic obstructive pulmonary disease, pneumonia, history of hospital-acquired infections, and prior sepsis. HIV-1-infected subjects had greater illness severity by Acute Physiology and Chronic Health Evaluation II scores (29 [24-31] vs 24 [22-25]; P.01). Hospital mortality was not higher among HIV-1-infected subjects compared with HIV-1-uninfected subjects (50.0% vs 38.4%; P = .19).In patients with ARDS, HIV-1 infection was associated with greater illness severity but was not associated with higher mortality in ARDS. Future studies need to be done to evaluate the factors that contribute to high morbidity and mortality in medically vulnerable populations who develop ARDS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect