| Autor: |
Vaghi, Matilde M, Moutoussis, Michael, Váša, František, Kievit, Rogier A, Hauser, Tobias U, Vértes, Petra E, Shahar, Nitzan, Romero-Garcia, Rafael, Kitzbichler, Manfred G, Bullmore, Edward T, NSPN Consortium, Dolan, Raymond J |
| Přispěvatelé: |
Moutoussis, Michael [0000-0002-4751-0425], Kievit, Rogier A [0000-0003-0700-4568], Hauser, Tobias U [0000-0002-7997-8137], Vértes, Petra E [0000-0002-0992-3210], Shahar, Nitzan [0000-0002-1364-6738], Kitzbichler, Manfred G [0000-0002-4494-0753], Bullmore, Edward T [0000-0002-8955-8283], Apollo - University of Cambridge Repository |
| Rok vydání: |
2020 |
| Předmět: |
|
| DOI: |
10.17863/cam.55710 |
| Popis: |
A characteristic of adaptive behavior is its goal-directed nature. An ability to act in a goal-directed manner is progressively refined during development, but this refinement can be impacted by the emergence of psychiatric disorders. Disorders of compulsivity have been framed computationally as a deficit in model-based control, and have been linked also to abnormal frontostriatal connectivity. However, the developmental trajectory of model-based control, including an interplay between its maturation and an emergence of compulsivity, has not been characterized. Availing of a large sample of healthy adolescents (n = 569) aged 14 to 24 y, we show behaviorally that over the course of adolescence there is a within-person increase in model-based control, and this is more pronounced in younger participants. Using a bivariate latent change score model, we provide evidence that the presence of higher compulsivity traits is associated with an atypical profile of this developmental maturation in model-based control. Resting-state fMRI data from a subset of the behaviorally assessed subjects (n = 230) revealed that compulsivity is associated with a less pronounced change of within-subject developmental remodeling of functional connectivity, specifically between the striatum and a frontoparietal network. Thus, in an otherwise clinically healthy population sample, in early development, individual differences in compulsivity are linked to the developmental trajectory of model-based control and a remodeling of frontostriatal connectivity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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