The fibrinolytic enzyme system in the newborn
| Autor: | Fritz K. Beller, Manfred D. Epstein, Gordon Watkins Douglas |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
medicine.medical_specialty
Plasmin Placenta Streptokinase In Vitro Techniques Fibrinogen Umbilical Cord Fibrinolytic Agents Pregnancy Internal medicine medicine Humans Fibrinolysin Aminocaproates Urokinase Fetus Activator (genetics) business.industry Infant Newborn Obstetrics and Gynecology Plasminogen In vitro Enzymes Endocrinology Cord blood Immunology Female Blood Coagulation Tests business medicine.drug |
| Zdroj: | American Journal of Obstetrics and Gynecology. 96:977-984 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/0002-9378(66)90443-1 |
| Popis: | 1. 1. In confirmation of previous reports the plasminogen level in cord blood is shown to be low and decreases further in the first days of life. 2. 2. Plasmin, urokinase, and streptokinase inhibitor levels are in the normal adult ranges. 3. 3. Activator is present in cord blood and is considered to be responsible for spontaneous lysis in vitro when fibrinogen is used as a substrate. 4. 4. Wharton's jelly and umbilical vessels are free of tissue activator. 5. 5. If the activator inhibitor EACA is infused to pregnant women during labor, it passes the placental barrier, is found in the cord blood, and inhibits activator in the fetal blood. Plasminogen remains at the same low level, indicating that the decrease in plasminogen is not caused by consumption, but is due to a lack of synthesis by the immature liver. 6. 6. The fibrinolytic system in the newborn is considered as a physiologic protective mechanism against untoward clot formation. |
| Databáze: | OpenAIRE |
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