Primary bone anaplastic lymphoma kinase positive anaplastic large-cell lymphoma: A case report and review of the literature
| Autor: | Wen-Hao Wu, Hai-Jun Huang, Meijuan Chen, Wei Zheng, Yi-Cheng Huang, Qiaoqiao Yin, Hongying Pan, Tian-Chen Hui, Rong Yan, Qingqing Wu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Osteolysis
Anaplastic lymphoma kinase 03 medical and health sciences 0302 clinical medicine immune system diseases hemic and lymphatic diseases Case report mental disorders medicine Anaplastic large-cell lymphoma Anaplastic large cell lymphoma business.industry General Medicine Primary bone lymphoma medicine.disease Lymphoma Primary Bone Lymphoma Primary bone 030220 oncology & carcinogenesis Cancer research Bone involvement 030211 gastroenterology & hepatology business Anaplastic Lymphoma Kinase Positive |
| Zdroj: | World Journal of Clinical Cases |
| ISSN: | 2307-8960 |
| DOI: | 10.12998/wjcc.v9.i14.3403 |
| Popis: | BACKGROUND Primary bone lymphoma (PBL) is an uncommon extranodal disease that represents approximately 1%-3% of lymphomas. Anaplastic lymphoma kinase (ALK) positive anaplastic large-cell lymphoma (ALCL) is an extremely rare type of PBL. The aim of this report is describe the symptoms, diagnosis, and treatment of primary bone ALK-positive ALCL. CASE SUMMARY A 66-year-old man presented to our hospital with neck and shoulder pain and intermittent fever that lasted for 1 mo. After extensive evaluation, positron emission tomography-computed tomography (CT) examination showed multiple osteolytic bone lesions without other sites lesions. CT-guided biopsy of the T10 vertebral body was performed, and the pathology results showed that neoplastic cells were positive for ALK-1, CD30, and CD3. A diagnosis of primary bone ALK positive ALCL was ultimately made. The patient was in partial response after four cycle soft cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy, and we planned to repeat the biopsy and radiological examination after completion of the fifth cycle of therapy. CONCLUSION Primary bone ALK positive ALCL is a rare disease and physicians should keep in mind that ALCL can present with isolated osseous involvement without nodal involvement, and lymphoma should be considered in the differential diagnosis of primary bone lesions. |
| Databáze: | OpenAIRE |
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