The Complement System Is Critical in Maintaining Retinal Integrity during Aging
| Autor: | Deeba Husain, John D. Lambris, Ryo Mukai, Kip M. Connor, Clifford Kim, Yoko Okunuki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
retina Cognitive Neuroscience Biology lcsh:RC321-571 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry complement system Original Research Retina Innate immune system aging Wild type Retinal 3. Good health Complement system Cell biology 030104 developmental biology medicine.anatomical_structure chemistry OCT EM ERG Inner nuclear layer Erg 030217 neurology & neurosurgery Homeostasis Neuroscience |
| Zdroj: | Frontiers in Aging Neuroscience, Vol 10 (2018) Frontiers in Aging Neuroscience |
| ISSN: | 1663-4365 |
| Popis: | The complement system is a key component of innate immunity comprised of soluble components that form a proteolytic cascade leading to the generation of effector molecules involved in cellular clearance. This system is highly activated not only under general inflammatory conditions such as infections, collagen diseases, nephritis, and liver diseases, but also in focal ocular diseases. However, little is known about the role of the complement system in retinal homeostasis during aging. Using young (6-week-old) and adult (6-month-old) mice in wild type (C57BL/6) and complement knockout strains (C1q−/−, Mbl a/c−/−, Fb−/−, C3−/−, and C5−/−), we compared amplitudes of electroretinograms (ERG) and thicknesses of retinal layers in spectral domain optical coherence tomography between young and adult mice. The ERG amplitudes in adult mice were significantly decreased (p < 0.001, p < 0.0001) compared to that of young mice in all complement knockout strains, and there were significant decreases in the inner nuclear layer (INL) thickness in adult mice compared to young mice in all complement knockout strains (p < 0.0001). There were no significant differences in ERG amplitude or thickness of the INL between young and adult control mice. These data suggest that the complement system plays an important role in maintaining normal retinal integrity over time. |
| Databáze: | OpenAIRE |
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