Exploratory drive, fear, and anxiety are dissociable and independent components in foraging mice
Autor: | Florian P. Binder, Vivian A. Schöttle, Carsten T. Wotjak, Tim Ebert, Daniel E. Heinz, Katharina Domschke, Paulina Nemcova |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Elevated plus maze
medicine.drug_class Physiology Foraging Neurosciences. Biological psychiatry. Neuropsychiatry Reinforcement sensitivity theory Anxiety Anxiolytic Open field Article Cellular and Molecular Neuroscience Mice Anti-Anxiety Agents medicine Avoidance Learning Animals Psychology Maze Learning Biological Psychiatry Behavior Animal Fear Anxiety Disorders Psychiatry and Mental health Exploratory Behavior medicine.symptom Neuroscience Mania RC321-571 |
Zdroj: | Translational Psychiatry, Vol 11, Iss 1, Pp 1-12 (2021) Translational Psychiatry |
ISSN: | 2158-3188 |
Popis: | Anxiety-like behavior of rodents is frequently accompanied by reduced exploration. Here, we identify dissociable components of anxiety, fear, and exploratory drive of sated and foraging mice. With the help of behavioral assays, including the open field task, elevated plus maze, dark–light transition task, and beetle mania task, we demonstrate a general increase in exploration by food restriction. Food-restricted mice bred for high anxiety behavior (HAB) showed ameliorated anxiety- but not fear-related behavior. By means of principal component analysis, we identified three independent components, which resemble the behavioral dimensions proposed by Gray’s Reinforcement Sensitivity Theory (approach behavior, avoidance behavior, and decision making). Taken together, we demonstrate anxiolytic consequences of food restriction in a mouse model of anxiety disorders that can be dissociated from a general increase in foraging behavior. |
Databáze: | OpenAIRE |
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