Incidental early diagnosis of biphasic pulmonary blastoma in a patient with history of stage IV lung adenocarcinoma
| Autor: | Priyanka Mittar, Sachin Gupta, William Tester, Sorab Gupta, Kunhwa Kim, Corrado Minimo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Pathology medicine.medical_specialty Case Report Biphasic pulmonary blastoma Disease Case Reports lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine medicine Adenocarcinoma of the lung Stage (cooking) next generation sequencing Lung business.industry Biphasic Pulmonary Blastoma Histology General Medicine medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens high mutational burden 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Adenocarcinoma second primary cancer Stage iv business |
| Zdroj: | Thoracic Cancer Thoracic Cancer, Vol 11, Iss 10, Pp 3029-3033 (2020) |
| ISSN: | 1759-7714 1759-7706 |
| Popis: | Biphasic pulmonary blastoma is a rare but lethal type of lung malignancy with characteristic histology of both epithelial and mesenchymal components. Previously reported cases have been limited to presentation at advanced stages, suggesting that the clinical course of the disease is usually aggressive. Here, we report a case of incidental diagnosis of biphasic pulmonary blastoma by imaging surveillance in a patient previously treated for adenocarcinoma of the lung. The patient was diagnosed with stage 1 disease and underwent successful resection. Next‐generation sequencing (NGS) revealed a high mutation burden, a finding not previously reported in a patient with biphasic pulmonary blastoma. Here, we report a rare case of incidental early diagnosis of biphasic pulmonary blastoma while a patient was undergoing imaging surveillance for primary lung adenocarcinoma. Next‐generation sequencing revealed distinct second primary cancer with a high mutation burden which might have therapeutic implications in further studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |