Study of Efficacy of Intraoral Submucosal Injections of Corticosteroids and Placentrex in the Management of Oral Submucous Fibrosis

Autor: C. Niranjan Reddy, Rajesh Radhakrishna Havaldar, B. P. Belaldavar
Rok vydání: 2020
Předmět:
Zdroj: Indian Journal of Otolaryngology and Head & Neck Surgery. 74:1996-2001
ISSN: 0973-7707
2231-3796
DOI: 10.1007/s12070-020-01965-z
Popis: In a country such as India, popularly known for its rich diversity and traditions, chewing tobacco and its many other forms is a commonly practised entity. The resultant of this leads to oral submucous fibrosis (OSMF) which causes permanent morbidity in the form of trismus and also can lead to potential possibility of oral cancer. Intra oral injections of steroids such as hyaluronidase and placentrex have been postulated by many studies. But this study was done to evaluate the efficacy of both these commonly used treatment modalities. A 1 year hospital based study was performed over 30 patients diagnosed to be having oral submucosal fibrosis. They were randomly given injection hyaluronidase and injection placentrex. In addition to this, routine haemogram was done and the inter incisor distance was measured before and after the treatment along with histopathological study of the oral lesions. With a prevalence of 0.31%, the males out numbered females. Majority of the patients were in their third decade. All patients chewed tobacco in one or the other form and 90% of them presented with burning sensation in the mouth. The mean inter incisor distance in our patients was 3.1%. A third of the cases were anaemic and two thirds had an elevated erythrocyte sedimentation rate and serum globulin level. More than half the cases had an elevated absolute eosinophil count. All 30 biopsy specimens showed atrophic oral mucosa with subepithelial dense collagenised fibrous tissue. The group of patients who were treated with injection placentrex showed slightly better results than corticosteroids. The results were not statistically significant although clinically they were noteworthy. Being a silent, chronic disease, oral submucosal fibrosis affects the most productive population fraction of our country causing morbidity and also acts as precursor for oral cancer. Since the etiological agent is chewing areacnut in one form or the other, considerable efforts have to be made in sensitizing the workforce of the nation at the community level in understanding the ill effects of chewing tobacco. Understanding the associated conditions such as anaemia, elevated erythrocyte sedimentation rate, serum globulins and absolute eosinophil count should prompt the otolaryngologist in treating these patients holistically. Though injection placentrex yielded better improvement in the inter incisor distance, the results with steroid injection was also comparable with no statistical significance. Hence, keeping the premalignant nature of the disease, screening the patients promptly and treating them on time would lead to considerable reduction in the morbidity caused by the disease. Coupled with health education, the results could be even more encouraging.
Databáze: OpenAIRE
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