Late endothelial function of free and pedicled internal mammary artery grafts
| Autor: | Andrew G. Mitchell, Sudhir S. Kushwaha, Magdi H. Yacoub, Charles Ilsley, Samad Tadjkarimi, Mahmud Bustami |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty business.industry education Substance P Vasodilation Peptide hormone Surgery Doubling dose chemistry.chemical_compound medicine.anatomical_structure chemistry medicine Mammary artery Derivation Isosorbide dinitrate Vein business Cardiology and Cardiovascular Medicine medicine.drug |
| Zdroj: | The Journal of Thoracic and Cardiovascular Surgery. 110(2):453-462 |
| ISSN: | 0022-5223 |
| DOI: | 10.1016/s0022-5223(95)70242-3 |
| Popis: | The internal mammary artery has greater long-term patency than the saphenous vein when used for coronary bypass grafting. Therefore, bilateral use of the internal mammary artery for grafting with the right internal mammary artery used as a "free" graft may result in improved graft survival. The study objectives were to compare the endothelial-dependent and -independent vasodilatory response in free and pedicled internal mammary artery grafts in patients who had previously undergone coronary surgery. Free (group 1, n = 8) and pedicled (group 2, n = 7) internal mammary artery grafts were studied by comparing the response to selective infusion of the endothelial-dependent vasodilator substance P (1.4 up to 22.4 pmol/min in doubling dose increments) followed by isosorbide dinitrate (2 mg over 2 minutes), in patients undergoing coronary angiography, 1 month to 6 years after coronary surgery. Maximal dilatory response to substance P was 8.7% ± 1.8% in pedicled grafts compared with 8.8% ± 2.3% in free grafts ( p = not significant), with the dose response for both groups being similar. Infusion of isosorbide dinitrate produced only minimal further dilatation in both groups. No significant difference was found in endothelium-dependent and -independent vasodilatory response between free and pedicled internal mammary artery grafts, suggesting that the use of the free right internal mammary artery and other arterial grafts may enhance graft survival. (J THORAC CARDIOVASC SURG 1995;110:453-62) |
| Databáze: | OpenAIRE |
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