Circulating proinflammatory cytokines and N-terminal pro-brain natriuretic peptide significantly decrease with recovery of left ventricular function in patients with dilated cardiomyopathy
| Autor: | Parminder S Otaal, Madhu Khullar, Rohit Manoj, M. Thungapathra, Uma Nahar Saikia, Ajay Bahl, Shamim Ahmad, Kewal K. Talwar, Taranjit Singh Rai |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Cardiomyopathy Dilated Male medicine.medical_specialty medicine.drug_class Clinical Biochemistry Cardiomyopathy Ventricular Function Left Proinflammatory cytokine Young Adult Internal medicine Natriuretic Peptide Brain Cytokine Receptor gp130 medicine Natriuretic peptide Humans Receptors Tumor Necrosis Factor Type II cardiovascular diseases Interleukin 6 Receptor Molecular Biology Inflammation Ejection fraction biology Interleukin-6 Tumor Necrosis Factor-alpha business.industry Case-control study Dilated cardiomyopathy Cell Biology General Medicine Middle Aged Prognosis medicine.disease Peptide Fragments Receptors Tumor Necrosis Factor Type I Case-Control Studies cardiovascular system biology.protein Cardiology Cytokines Female business Biomarkers |
| Zdroj: | Molecular and Cellular Biochemistry. 324:139-145 |
| ISSN: | 1573-4919 0300-8177 |
| DOI: | 10.1007/s11010-008-9992-1 |
| Popis: | Background Increased levels of TNF-α, IL-6, their soluble receptors, and NT-proBNP have been observed in patients with dilated cardiomyopathy (DCM). In the present study, we assessed the possible involvement of proinflammatory cytokines and their soluble receptors with and without recovery of LV function in DCM patients. Methodsandresults Forty patients with DCM were enrolled and divided into two groups: Group I consisted of DCM patients (n = 30) whose left ventricular ejection fraction (LVEF) had not recovered on follow up and Group II comprised DCM patients (n = 10) whose LVEF had recovered. Ten healthy subjects were included as controls (Group III). TNF-α, IL-6,TNFR1, TNFRII, gp130, and NT-proBNP levels were significantly increased in Group I and were significantly lower in patients with LVEF recovery as compared to those without recovery of LVEF (P < 0.05). Conclusion Circulating TNF-α, IL-6, and NT-proBNP appear to correlate with the LV function recovery of patients with DCM and could be used as prognostic biomarkers. |
| Databáze: | OpenAIRE |
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