Does parental farm upbringing influence the risk of asthma in offspring? : a three-generation study
Autor: | Julia Dratva, Signe Timm, Torben Sigsgaard, Linus Schiöler, Randi Jacobsen Bertelsen, Cecilie Svanes, José Luis Sánchez-Ramos, Shyamali C. Dharmage, Jesus Martinez-Moretalla, Lennart Bråbäck, Brittany Campbell, Morten Frydenberg, Vivi Schlünssen, Mathias Holm, Marie Kjær Madsen, Rain Jõgi, Ane Johannessen, Christer Janson, Nils Oskar Jõgi |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Parents
0301 basic medicine Farms Epidemiology Offspring Asthma phenotypes Generation study Lower risk ECRHS 616: Innere Medizin und Krankheiten 03 medical and health sciences 0302 clinical medicine Risk Factors medicine Humans 030212 general & internal medicine Generational effects Reference group Asthma generational effects Hazard ratio Australia General Medicine asthma medicine.disease generation study Confidence interval Questionnaire data 614: Public Health und Gesundheitsförderung RHINESSA Europe farm upbringing 030104 developmental biology Spain Psychology Farm upbringing Demography |
Zdroj: | Timm, S, Svanes, C, Frydenberg, M, Sigsgaard, T, Holm, M, Janson, C, Bråbäck, L, Campbell, B, Kjaer Madsen, M, Jõgi, N O, Jõgi, R, Schiöler, L, Bertelsen, R J, Johannessen, A, Sanchez-Ramos, J L, Martinez-Moretalla, J, Dratva, J, Dharmage, S & Schlünssen, V 2020, ' Does parental farm upbringing influence the risk of asthma in offspring? A three-generation study ', International Journal of Epidemiology, vol. 49, no. 6, dyaa091 . https://doi.org/10.1093/ije/dyaa091 |
DOI: | 10.21256/zhaw-21291 |
Popis: | Erworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch) Background: A farm upbringing has been associated with lower risk of asthma and methylation of asthma-related genes. As such, a farm upbringing has the potential to transfer asthma risk across generations, but this has never been investigated. We aimed to study the generational effects from a parental farm upbringing on offspring asthma. Methods: Our study involved three generations: 5759 participants from the European Community Respiratory Health Survey (ECRHS) study (born 1945–1971, denoted G1), their 9991 parents (G0) and their 8260 offspring (G2) participating in RHINESSA (Respiratory Health In Northern Europe, Spain and Australia). Questionnaire data were collected on G0 and G1 from G1 in 2010 and on G2 from themselves in 2013. The parental/grandparental place of upbringing was categorized: (i) both parents from farm; (ii) mother from farm, father from village/city; (iii) father from farm, mother from village/city; (iv) both parents from village or one parent from village and one from city; (v) both parents from city (reference group). Grandparental upbringing was equivalently categorized. Offspring asthma was self-reported and data were analysed using Cox-regression models with G2 age as the time scale. Results: A parental farm upbringing was not associated with offspring asthma when compared with city upbringing [hazard ratio (HR) 1.12, 95% confidence interval (CI) 0.74–1.69]. Findings remained similar when stratified by offspring upbringing and asthma phenotypes. Quantitative bias analyses showed similar estimates for alternative data sources. A grandparental farm upbringing was not associated with offspring asthma in either the maternal (HR 1.05, 95% CI 0.67–1.65) or paternal line (HR 1.02, 95% CI 0.62–1.68). Conclusions: This multigenerational analysis suggests no evidence of an association between parental/grandparental farm upbringing and offspring asthma. |
Databáze: | OpenAIRE |
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