Insights from a Prospective Follow-up of Thyroid Function and Autoimmunity among COVID-19 Survivors
| Autor: | Kelvin K. W. To, Chi Ho Lee, Anthony Raymond Tam, Chun Yiu Law, Alan Chun Hong Lee, Wing Sun Chow, David T W Lui, Ivan Hung, Karen S.L. Lam, Ching-Wan Lam, Carol H.Y. Fong, Yu Cho Woo, Eunice Ka Hong Leung, Kathryn C.B. Tan |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty endocrine system China Thyroiditis endocrine system diseases Endocrinology Diabetes and Metabolism media_common.quotation_subject Autoimmunity Thyroid Function Tests Thyroid function tests Gastroenterology Diseases of the endocrine glands. Clinical endocrinology Endocrinology Patient Admission Internal medicine Medicine Humans Prospective Studies Survivors Prospective cohort study media_common Thyroid Thyroid gland medicine.diagnostic_test business.industry SARS-CoV-2 Convalescence Euthyroid sick syndromes Antibody titer Thyroiditis Autoimmune COVID-19 Middle Aged medicine.disease RC648-665 Thyroid Diseases medicine.anatomical_structure Female Original Article Thyroid function business Euthyroid sick syndrome Follow-Up Studies |
| Zdroj: | Endocrinology and Metabolism Endocrinology and Metabolism, Vol 36, Iss 3, Pp 582-589 (2021) |
| ISSN: | 2093-5978 |
| Popis: | Background The occurrence of Graves’ disease and Hashimoto thyroiditis after coronavirus disease 2019 (COVID-19) raised concerns that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may trigger thyroid autoimmunity. We aimed to address the current uncertainties regarding incident thyroid dysfunction and autoimmunity among COVID-19 survivors. Methods We included consecutive adult COVID-19 patients without known thyroid disorders, who were admitted to Queen Mary Hospital from July 21 to September 21, 2020 and had serum levels of thyroid-stimulating hormone, free thyroxine, free triiodothyronine (fT3), and anti-thyroid antibodies measured both on admission and at 3 months. Results In total, 122 patients were included. Among 20 patients with abnormal thyroid function tests (TFTs) on admission (mostly low fT3), 15 recovered. Among 102 patients with initial normal TFTs, two had new-onset abnormalities that could represent different phases of thyroiditis. Among 104 patients whose anti-thyroid antibody titers were reassessed, we observed increases in anti-thyroid peroxidase (TPO) (P12 U, and four became anti-TPO-positive. Worse baseline clinical severity (P=0.018), elevated C-reactive protein during hospitalization (P=0.033), and higher baseline anti-TPO titer (P=0.005) were associated with a significant increase in anti-TPO titer. Conclusion Most patients with thyroid dysfunction on admission recovered during convalescence. Abnormal TFTs suggestive of thyroiditis occurred during convalescence, but infrequently. Importantly, our novel observation of an increase in anti-thyroid antibody titers post-COVID-19 warrants further follow-up for incident thyroid dysfunction among COVID-19 survivors. |
| Databáze: | OpenAIRE |
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