Global variation in SARS-CoV-2 proteome and its implication in pre-lockdown emergence and dissemination of 5 dominant SARS-CoV-2 clades
| Autor: | Patil Pranita Uttamrao, L. Ponoop Prasad Patro, Chakkarai Sathyaseelan, Thenmalarchelvi Rathinavelan |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) SARS-CoV-2 viromics Proteome Phyloproteomics Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Proteome analysis 030106 microbiology Biology Virus Replication medicine.disease_cause Microbiology Genome Mutational susceptibility Viral Proteins 03 medical and health sciences Pandemic Genetics medicine Humans Clade Molecular Biology Ecology Evolution Behavior and Systematics Mutation Whole Genome Sequencing SARS-CoV-2 Moderately recurring mutations COVID-19 Biological Evolution Hospitalization 030104 developmental biology Infectious Diseases Highly recurring mutations Viral evolution Spike Glycoprotein Coronavirus Gene sequence Research Paper |
| Zdroj: | Infection, Genetics and Evolution |
| ISSN: | 1567-1348 |
| Popis: | SARS-CoV-2 is currently causing major havoc worldwide with its efficient transmission and propagation. To track the emergence as well as the persistence of mutations during the early stage of the pandemic, a comparative analysis of SARS-CoV-2 whole proteome sequences has been performed by considering manually curated 31,389 whole genome sequences from 84 countries. Among the 7 highly recurring (percentage frequency≥10%) mutations (Nsp2:T85I, Nsp6:L37F, Nsp12:P323L, Spike:D614G, ORF3a:Q57H, N protein:R203K and N protein:G204R), N protein:R203K and N protein: G204R are co-occurring (dependent) mutations. Nsp12:P323L and Spike:D614G often appear simultaneously. The highly recurring Spike:D614G, Nsp12:P323L and Nsp6:L37F as well as moderately recurring (percentage frequency between ≥1 and Graphical abstract Unlabelled Image |
| Databáze: | OpenAIRE |
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