d-Arabitol Ameliorates Obesity and Metabolic Disorders via the Gut Microbiota-SCFAs-WAT Browning Axis

Autor: Xiaolan Li, Jian Huang, Junhua Yun, Guoyan Zhang, Yufei Zhang, Mei Zhao, Hossain M. Zabed, Yuvaraj Ravikumar, Xianghui Qi
Rok vydání: 2022
Předmět:
Zdroj: Journal of agricultural and food chemistry.
ISSN: 1520-5118
Popis: d-Arabitol, which is typically found in mushrooms, lichens, and higher fungi, might play an effective role in alleviating visceral fat accumulation and insulin resistance particularly for its low calorie and glycemic index. However, the regulatory mechanisms of d-arabitol for alleviating obesity and associated metabolic disorders remain poorly understood. This study aimed to investigate and analyze the underlying relationship between d-arabitol-mediated gut microbiota and obesity. The results showed that d-arabitol dramatically ameliorated body weight gain, fat accumulation, and insulin resistance in HFD-fed rats. Likewise, d-arabitol remarkably increased the relative abundance of the genera
Databáze: OpenAIRE