Invasive mycotic and actinomycotic oropharyngeal and craniofacial infection in two patients with AIDS
Autor: | A. Mazzoni, O. Cavicchi, Donatella Santini, Roberto Manfredi, Francesco Chiodo |
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Rok vydání: | 1994 |
Předmět: |
Adult
Nasal cavity medicine.medical_specialty Pathology Opportunistic infection Dermatology Aspergillosis Actinomycosis Immunopathology medicine Humans Craniofacial Gynecology AIDS-Related Opportunistic Infections biology Palate business.industry Candidiasis Pharyngitis General Medicine biology.organism_classification medicine.disease Infectious Diseases medicine.anatomical_structure Mycoses Female Hard palate business Actinomyces |
Zdroj: | Mycoses. 37:209-215 |
ISSN: | 1439-0507 0933-7407 |
DOI: | 10.1111/j.1439-0507.1994.tb00302.x |
Popis: | Summary. Two cases of invasive oropharyngeal and craniofacial infection caused by fungal and actinomycotic pathogens are described in HIV-infected patients. Two women with a previous diagnosis of AIDS, one with non-Hodgkin's lymphoma and one with Candida oesophagitis, developed a subacute, invasive inflammatory process characterized by ulcerative neorotizing lesions spreading from the oropharynx up to the soft and hard palate, maxillary sinuses and nasal cavity, with extensive soft-tissue necrosis. Although presenting with a very similar clinical picture, infection was due to Actinomyces spp. in the first case, while an apparent dual fungal aetiology (Aspergillus flaws and Candida spp.) was demonstrated in the second patient. Both cases were characterized by remarkable diagnostic difficulties leading to a late final recognition (confirmed by histological examination), and by a partial response to antimicrobial treatment. Zusammenfassung. Es werden zwei Falle invasiver oropharyngealer und kraniofazialer Infektionen, einmal durch Strahlenpilze, das andere Mal durch Pilze bedingt, an HIV-positiven Patienten vorgestellt. Zwei Frauen mit AIDS, Non-Hodgkin-Lymphom sowie Candida-Osophagitis entwickelten einen subakuten, invasiventzundlichen Prozes, charakterisiert durch ulzerierende Nekrosen, die sich vom Oropharynx zum weichen und harten Gaumen, zu den Kieferhohlen und dem Nasenraum ausbreiteten. Obgleich sich beide Situationen im klinischen Bild stark ahnelten, war der erste Prozes durch Actinomyces spp., der zweite durch eine Doppelinfektion von Aspergillus flavus und Candida spp. bedingt. In beiden Fallen war die Diagnose schwierig, was zu spater atiologischer Abklarung und zu nur teilweisem Ansprechen auf die antimikrobielle Chemotherapie fuhrte. |
Databáze: | OpenAIRE |
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