Antibacterial PEGylated Solid Lipid Microparticles for Cosmeceutical Purpose: Formulation, Characterization, and Efficacy Evaluation

Autor: Denise Murgia, Alessandro Presentato, Maria Cristina D'Oca, Amalia Giulia Scarpaci, Giuseppe Angellotti, Rosa Alduina, Maria Valeria Raimondi, Viviana De Caro
Přispěvatelé: Angellotti, Giuseppe, Murgia, Denise, Presentato, Alessandro, D'Oca, Maria Cristina, Scarpaci, Amalia Giulia, Alduina, Rosa, Raimondi, Maria Valeria, De Caro, Viviana
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Antioxidant
tape-stripping
medicine.medical_treatment
02 engineering and technology
Resveratrol
Labrasol
Settore BIO/19 - Microbiologia Generale
01 natural sciences
lcsh:Technology
porcine ear
chemistry.chemical_compound
lipid microsphere
General Materials Science
Acne
media_common
lcsh:QC120-168.85
1-Hexadecanol
021001 nanoscience & nanotechnology
Antimicrobial
medicine.anatomical_structure
0210 nano-technology
Cosmeceutical
lcsh:TK1-9971
Drug
media_common.quotation_subject
Absorption (skin)
Staphylococcus aureus ATCC 25923
Article
lipid microspheres
medicine
Stratum corneum
lcsh:Microscopy
antimicrobial activity
porcine ears
lcsh:QH201-278.5
010405 organic chemistry
lcsh:T
medicine.disease
Combinatorial chemistry
0104 chemical sciences
chemistry
lcsh:TA1-2040
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
solid lipid microparticle
lcsh:Descriptive and experimental mechanics
solid lipid microparticles
lcsh:Electrical engineering. Electronics. Nuclear engineering
lcsh:Engineering (General). Civil engineering (General)
Limonene
Zdroj: Materials
Volume 13
Issue 9
Materials, Vol 13, Iss 2073, p 2073 (2020)
ISSN: 1996-1944
DOI: 10.3390/ma13092073
Popis: The development of efficacious means of delivering antioxidant polyphenols from natural sources for the treatment of skin diseases is of great interest for many cosmetic and pharmaceutical companies. Resveratrol (RSV) and Limonene (LIM) have been shown to possess good anti-inflammatory and antibacterial properties against Staphylococcus aureus infections responsible for many skin disorders, such as acne vulgaris. In this study, solid lipid microparticles are designed as composite vehicles capable of encapsulating a high amount of trans-RSV and enhancing its absorption through the stratum corneum. A microparticulate system based on mixture of PEGylate lipids, long-chain alcohols and LIM is able to entrap RSV in an amorphous state, increasing its half-life and avoiding inactivation due to isomerization phenomena, which represents the main drawback in topical formulations. Particles have been characterized in term of shape, size distribution and drug loading. Antimicrobial tests against S. aureus have highlighted that empty microspheres possess per se antimicrobial activity, which is enhanced by the presence of LIM, demonstrating that they can represent an interesting bactericide vehicle for RSV administration on the skin.
Databáze: OpenAIRE
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