European society of clinical microbiology and infectious diseases guidelines for coronavirus disease 2019: an update on treatment of patients with mild/moderate disease
| Autor: | Michele Bartoletti, Ozlem Azap, Aleksandra Barac, Linda Bussini, Onder Ergonul, Robert Krause, Alejandro Martin-Quiros, José Ramón Paño-Pardo, Nicholas Power, Marcella Sibani, Balint Gergely Szabo, Sotirios Tsiodras, Ines Zollner-Schwetz, Jesús Rodríguez-Baño |
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| Přispěvatelé: | Ergönül, Mehmet Önder (ORCID 0000-0003-1935-9235 & YÖK ID 110398), Bartoletti, M., Azap, O., Barac, A., Bussini, L., Krause, R., Martin Quiros, A., Paño-Pardo, J.R., Power, N., Sibani, M., Szabo, B.G., Tsiodras, S., Zollner-Schwetz, I., Rodríguez-Baño, J., Koç Üniversitesi İş Bankası Enfeksiyon Hastalıkları Uygulama ve Araştırma Merkezi (EHAM) / Koç University İşbank Center for Infectious Diseases (KU-IS CID), Koç University Hospital, School of Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Clinical Microbiology and Infection |
| Popis: | [Scope] Despite the large availability of vaccines, coronavirus disease 2019 (COVID-19), induced by severe acute respiratory syndrome coronavirus 2, continues to be a major threat for health-care providers and fragile people. A number of options are now available for outpatients with mild-to-moderate COVID-19 at the risk of disease progression for the prevention of deaths or hospitalization. [Methods] A European Society of Clinical Microbiology and Infectious Diseases COVID-19 guidelines task force was established by the European Society of Clinical Microbiology and Infectious Diseases Executive Committee. A small group was established, half appointed by the chair and the remaining selected based on an open call. Each panel met virtually once a week. For all decisions, a simple majority vote was used. A long list of clinical questions using the population, intervention, comparison, outcome format was developed at the beginning of the process. For each population, intervention, comparison, outcome, two panel members performed a literature search, with a third panelist involved in case of inconsistent results. Voting was based on the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. [Recommendations] In this update, we focus on anti-viral agents, monoclonal antibodies (mAbs) and other treatment options proposed for patients with mild or moderate COVID-19 who are at the risk of hospitalization or death. Although the use of anti-virals is recommended, especially nirmatrelvir/ritonavir and remdesivir or, alternatively, molnupirarvir, the administration of mAbs against the spike protein strictly depends on circulating variants or the ability to test timely for variants and sub-variants. At the time of writing (April–June 2022), the only active mAb was tixagevimab/cilgavimab given the predominance of the Omicron BA.2, BA.3, BA.4 and BA.5 sub-lineages in Europe. However, considering that the epidemiological scenario is extremely dynamic, constant monitoring of variants of concern is mandatory. |
| Databáze: | OpenAIRE |
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