Cognitive effects of lamotrigine versus topiramate as adjunctive therapy in older adults with epilepsy
| Autor: | Ann E. Hammer, Robert P. Kustra, Susan Kerls, Steve Chung |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Topiramate
Pediatrics medicine.medical_specialty lcsh:Internal medicine lcsh:Medicine Lamotrigine Article lcsh:RC321-571 Epilepsy Cognition Older patients medicine In patient Psychiatry lcsh:RC31-1245 lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry older patients business.industry lcsh:R Controlled Oral Word Association Test epilepsy lamotrigine topiramate cognition medicine.disease Cognitive test cognitive side effects Neurology (clinical) business medicine.drug |
| Zdroj: | Neurology International Neurology International; Volume 1; Issue 1; Pages: e6 Neurology International, Vol 1, Iss 1, Pp e6-e6 (2009) |
| ISSN: | 2035-8377 2035-8385 |
| Popis: | Older individuals may be more susceptible to cognitive side effects of antiepileptic drugs than are younger adults. This randomized, double-blind study compared the cognitive effects of lamotrigine (median maintenance dosage, 500.0 mg/d) and topiramate (median maintenance dosage, 300.0 mg/d) as adjunctive therapy for 16 weeks in patients ≥50 years of age. Fifty-one patients (lamotrigine, n=25; topiramate, n=26) were enrolled, and 28 patients (lamotrigine, n=15; topiramate, n=13) completed the study. In a combined analysis of all cognitive tests performed, no significant differences between treatment groups were noted. However, analyses of individual cognitive test results revealed that lamotrigine-treated patients had significantly better results on the Controlled Oral Word Association Test and the Symbol-Digit Modalities Test, whereas topiramate-treated patients had significantly more favorable results on the Digit Cancellation Test and the Rey Auditory-Verbal Learning Test. Larger studies are needed to further clarify the differences in the cognitive effects of lamotrigine and topiramate in older patients. |
| Databáze: | OpenAIRE |
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