The ketogenic diet as a therapeutic intervention strategy in mitochondrial disease
| Autor: | Changbo Qu, Merel J. W. Adjobo-Hermans, Melissa A.E. van de Wal, Werner J.H. Koopman, Yihang Pan, Clara D.M. van Karnebeek, Tom J.J. Schirris, Jaap Keijer |
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| Přispěvatelé: | ANS - Cellular & Molecular Mechanisms, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism |
| Rok vydání: | 2021 |
| Předmět: |
Mitochondrial ROS
Mitochondrial Diseases Bioenergetics medicine.medical_treatment Mitochondrial disease Oxidative phosphorylation Pharmacology Mitochondrion Biology Mitochondrial Dynamics Biochemistry All institutes and research themes of the Radboud University Medical Center Mitophagy medicine Animals Humans VLAG Metabolic Disorders Radboud Institute for Molecular Life Sciences [Radboudumc 6] Cell Biology Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] medicine.disease Mitochondria Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11] Human and Animal Physiology WIAS Fysiologie van Mens en Dier Ketone bodies Diet Ketogenic Energy Metabolism Oxidation-Reduction Ketogenic diet |
| Zdroj: | International Journal of Biochemistry & Cell Biology, 138 International Journal of Biochemistry and Cell Biology 138 (2021) international journal of biochemistry & cell biology, 138:106050. Elsevier Limited International Journal of Biochemistry and Cell Biology, 138 |
| ISSN: | 1357-2725 |
| Popis: | Classical mitochondrial disease (MD) represents a group of complex metabolic syndromes primarily linked to dysfunction of the mitochondrial ATP-generating oxidative phosphorylation (OXPHOS) system. To date, effective therapies for these diseases are lacking. Here we discuss the ketogenic diet (KD), being a high-fat, moderate protein, and low carbohydrate diet, as a potential intervention strategy. We concisely review the impact of the KD on bioenergetics, ROS/redox metabolism, mitochondrial dynamics and mitophagy. Next, the consequences of the KD in (models of) MD, as well as KD adverse effects, are described. It is concluded that the current experimental evidence suggests that the KD can positively impact on mitochondrial bioenergetics, mitochondrial ROS/redox metabolism and mitochondrial dynamics. However, more information is required on the bioenergetic consequences and mechanistic mode-of-action aspects of the KD at the cellular level and in MD patients. |
| Databáze: | OpenAIRE |
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