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Getachew Ashagrie,1,2 Fentaw Girmaw,1 Abebe Tarekegn,1 Tenaw Baye,1 Abebe Dagne3 1Department of Pharmacy, College of Health Science, Woldia University, Woldia, Ethiopia; 2Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia; 3Department of Pharmacy, College of Health science, Debre Markos University, Debre Markos, EthiopiaCorrespondence: Getachew Ashagrie, Email getachewashagrie16@gmail.comBackground: The roots of Impatiens rothii has been used as a traditional remedy for painful conditions, rheumatism, isthmus and crural aches. However, the analgesic and anti-inflammatory properties of this plant have yet to be scientifically confirmed. The purpose of this study was to explore possible analgesic and anti-inflammatory activities 80% methanolic root extract of Impatiens rothii.Methods: To obtain the crude extract, the roots of Impatiens rothii that had been dried and ground up were macerated in 80% methanol. The analgesic activity was determined using acetic acid-induced writhing and hot plate tests in mice, whereas the anti-inflammatory activity was analyzed using carrageenan-induced paw edema model in rats. The extract was orally administered at a dose of 100, 200 and 400 mg/kg.Results: All tested doses of Impatiens rothii extract showed significant analgesic activity (p< 0.05) at observations of 30 to 120 minutes compared to the negative control in the hot plate test. In acetic acid-induced writhing test all tested doses of the 80% methanol extract of Impatiens rothii significantly (p < 0.001) reduced the number of writhing. In comparison to the control group, all tested doses displayed a significant decrease in paw edema, which appeared 2â 5 hours after induction (p< 0.05).Conclusion: From the results of this study, it can be stated that 80% methanolic extract of Impatiens rothii possessed substantial analgesic and anti-inflammatory activities, hence providing scientific basis for the use of this plant in the treatment of pain and inflammatory diseases.Keywords: Impatiens rothii, analgesic, hot plate, anti-inflammatory, carrageenan- induced paw edema |
