Pseudomonas aeruginosa in French hospitals between 2001 and 2011: back to susceptibility

Autor: Slekovec, C., Robert, J., Trystram, D., Delarbre, J. M., Merens, A., Van Der Mee-Marquet, N., De Gialluly, C., Costa, Y., Caillon, J., Hocquet, D., Bertrand, X., Renseigné, Non
Přispěvatelé: Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Laboratoire Aimé Cotton (LAC), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-École normale supérieure - Cachan (ENS Cachan), Unité de recherche clinique Paris Nord (URC Paris Nord), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de bactériologie et hygiène hospitalière [Nantes], Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes), Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Hôpital Jean Minjoz, Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), Laboratoire Aimé Cotton ( LAC ), École normale supérieure - Cachan ( ENS Cachan ) -Université Paris-Sud - Paris 11 ( UP11 ) -Centre National de la Recherche Scientifique ( CNRS ), Unité de recherche clinique Paris Nord ( URC Paris Nord ), Assistance publique - Hôpitaux de Paris (AP-HP), Université de Nantes ( UN ) -Centre hospitalier universitaire de Nantes ( CHU Nantes )
Rok vydání: 2014
Předmět:
Microbiology (medical)
medicine.medical_specialty
medicine.drug_class
ANTIMICROBIAL SUSCEPTIBILITY
Cephalosporin
FRANCE
Antimicrobial susceptibility
Microbial Sensitivity Tests
Drug resistance
Biology
medicine.disease_cause
MECHANISMS
Microbiology
03 medical and health sciences
0302 clinical medicine
Medical microbiology
Antibiotic resistance
[ SDV.MP ] Life Sciences [q-bio]/Microbiology and Parasitology
Environmental Microbiology
Prevalence
medicine
Humans
030212 general & internal medicine
Carbapenem resistance
Cross Infection
0303 health sciences
030306 microbiology
Pseudomonas aeruginosa
STRAINS
General Medicine
Antimicrobial
GENE
Hospitals
Anti-Bacterial Agents
3. Good health
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
Infectious Diseases
METALLO-BETA-LACTAMASE
RESISTANCE
Zdroj: European Journal of Clinical Microbiology and Infectious Diseases
European Journal of Clinical Microbiology and Infectious Diseases, Springer Verlag, 2014, 33 (10), epub ahead of print. ⟨10.1007/s10096-014-2125-8⟩
European Journal of Clinical Microbiology and Infectious Diseases, Springer Verlag, 2014, epub ahead of print. 〈10.1007/s10096-014-2125-8〉
ISSN: 1435-4373
0934-9723
DOI: 10.1007/s10096-014-2125-8
Popis: International audience; : The European Antimicrobial Resistance Surveillance Network (EARS-Net) reported an increase in the rates of resistance of Pseudomonas aeruginosa to antimicrobials between 2008 and 2011 in France. This alarming report was based on data collected during the harmonisation of breakpoints by the European Committee on Antimicrobial Susceptibility Testing (EUCAST) committee. However, these data were not supported by the findings of other national surveillance networks. In this study, we assessed the trends in P. aeruginosa antimicrobial drug resistance at six French hospitals over a longer period of time (2001-2011) and with a constant definition of resistance. After the exclusion of incomplete data and duplicates, we sorted 34,065 isolates into the antimicrobial resistance patterns defined by the European Centre for Disease Prevention and Control (ECDC). The proportion of isolates with a resistant pattern (non-susceptible to one or two antimicrobial categories), a multidrug-resistant pattern (non-susceptible to three or four antimicrobial categories) or an extensively drug-resistant pattern (non-susceptible to five or six antimicrobial categories) decreased significantly over time. Logically, the proportion of isolates with a wild-type resistance pattern has increased significantly over the same period. No significant changes in the rates of resistance to cephalosporins and penicillins were observed, whereas carbapenem resistance rates increased. By contrast, the proportion of isolates resistant to fluoroquinolones, aminoglycosides and monobactams decreased significantly over time. In conclusion, our data do not confirm the EARS-net data, suggesting instead that antimicrobial drug resistance in P. aeruginosa might not have increased in French hospitals over the last decade.
Databáze: OpenAIRE
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