Akt scaffold proteins: the key to controlling specificity of Akt signaling
| Autor: | Su An, Peiqi Hao, Tian-Rui Xu, Xiao-Xi Guo, Ying Liu, Qian Hao, Fan Bao, Yang Yang, Mubashir Ejaz |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Scaffold protein Sodium-Hydrogen Exchangers Physiology Antineoplastic Agents Apoptosis Interactome Phosphatidylinositol 3-Kinases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Neoplasms Humans Molecular Targeted Therapy Phosphatidylinositol Phosphorylation Protein kinase B Adaptor Proteins Signal Transducing Cell Proliferation Cell growth Intracellular Signaling Peptides and Proteins Cell Biology Phosphoproteins Cell biology DNA-Binding Proteins Gene Expression Regulation Neoplastic 030104 developmental biology chemistry ras GTPase-Activating Proteins 030220 oncology & carcinogenesis Signal transduction Proto-Oncogene Proteins c-akt Signal Transduction |
| Zdroj: | American Journal of Physiology-Cell Physiology. 321:C429-C442 |
| ISSN: | 1522-1563 0363-6143 |
| Popis: | The phosphatidylinositol 3-kinase-Akt signaling pathway plays an essential role in regulating cell proliferation and apoptosis. Akt kinase is at the center of this signaling pathway and interacts with a variety of proteins. Akt is overexpressed in almost 80% of tumors. However, inhibiting Akt has serious clinical side effects so is not a suitable treatment for cancer. During recent years, Akt scaffold proteins have received increasing attention for their ability to regulate Akt signaling and have emerged as potential targets for cancer therapy. In this paper, we categorize Akt kinase scaffold proteins into four groups based on their cellular location: membrane-bound activator and inhibitor, cytoplasm, and endosome. We describe how these scaffolds interact with Akt kinase, how they affect Akt activity, and how they regulate the specificity of Akt signaling. We also discuss the clinical application of Akt scaffold proteins as targets for cancer therapy. |
| Databáze: | OpenAIRE |
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