Differentiation of aggressive from non-aggressive pancreatic solid pseudopapillary neoplasms using computed tomography
| Autor: | Hui Li, Cheng Wang, Jianhua Wang, Xiao Chen, Wenjing Cui, Zhongqiu Wang, Shuai Ren, Zhonglan Wang |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Urology Sensitivity and Specificity 030218 nuclear medicine & medical imaging Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Atrophy Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Neoplasm Invasiveness Pancreas Retrospective Studies Pancreatic duct Radiological and Ultrasound Technology Receiver operating characteristic business.industry Gastroenterology Area under the curve Hepatology medicine.disease Carcinoma Papillary Pancreatic Neoplasms medicine.anatomical_structure 030220 oncology & carcinogenesis Female Radiology Differential diagnosis business Tomography X-Ray Computed Calcification |
| Zdroj: | Abdominal radiology (New York). 44(7) |
| ISSN: | 2366-0058 |
| Popis: | Microscopic aggressive behaviors may be related with the prognosis of solid pseudopapillary neoplasms (SPNs). In this study, we investigate computed tomography (CT) features and differential diagnosis of aggressive and non-aggressive SPNs in pancreas.122 patients with pathologically proven SPNs in pancreas were included. Patients' age, tumor site, texture, shape, margins, exophytic growth, capsule, calcification, hemorrhage, pancreatic duct dilatation or pancreatic parenchyma atrophy, peripancreatic infiltration or metastases, vascular encasement, and enhancement pattern were assessed. The diagnostic accuracy was analyzed by using the receiver operating characteristic curve (ROC).There were 30 aggressive SPNs and 92 non-aggressive SPNs. Aggressive SPNs showed significantly higher frequencies of an ill-defined margin, patient age 40.5 years, and tumor size 42.1 mm, but lower frequencies of complete capsule, hemorrhage compared with non-aggressive SPNs (p 0.05). Lack of complete capsule and age 40.5 years were independent risk factors of aggressive SPNs (odd ratio 7.08 and 3.1, respectively). When we applied the two predictors in the logistic regression model, the area under the curve (AUC) was 0.77 with sensitivity of 86.7% and specificity of 55.4%.Size less than 42.1 mm, lack of complete capsule, ill-defined, and absent bleeding are useful CT imaging features for predicating aggressive SPNs. Patient age 40.5 years and lack of complete capsule showed acceptable diagnostic performance for discriminating aggressive from non-aggressive SPNs. |
| Databáze: | OpenAIRE |
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