How useful are ferric chloride models of arterial thrombosis?
| Autor: | Steven P. Grover, Nigel Mackman |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
inorganic chemicals
0301 basic medicine Blood Platelets Erythrocytes 030204 cardiovascular system & hematology Pharmacology Chloride Ferric Compounds 03 medical and health sciences Mice 0302 clinical medicine Chlorides medicine Animals Humans Platelet Carotid Artery Thrombosis Thrombus Mice Knockout Atherothrombotic disease Chemistry Anticoagulants Hematology General Medicine medicine.disease Thrombosis Disease Models Animal 030104 developmental biology Knockout mouse bacteria Ferric medicine.drug |
| Zdroj: | Platelets. 31(4) |
| ISSN: | 1369-1635 |
| Popis: | The ferric chloride models of arterial thrombosis are useful tools with which to investigate the cellular and molecular mechanisms that contribute to arterial thrombosis. Recent insights have, however, revealed the complex and multifaceted mechanism by which ferric chloride induces thrombus formation. Here, we discuss the strengths and weaknesses of the ferric chloride models of arterial thrombosis. Particular focus is given to the phenotypes of different knockout mice in the ferric chloride models and how these compare to other models with independent modes of initiation. Further, we discuss the relevance of the ferric chloride models to the human pathology of atherothrombotic disease. |
| Databáze: | OpenAIRE |
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