Risk factors for in-hospital mortality in patients with acute myocardial infarction during the COVID-19 outbreak

Autor: José Luis Zamorano, Enrique Gutiérrez Ibañes, Fernando Sarnago, Ignacio J. Amat-Santos, Ángel Sánchez-Recalde, Sandra Santos Martínez, Jorge Solano-López, Jessika González D’Gregorio, José Luis Mestre, Roberto Mateos Gaitán, Marcelo Sanmartín, Juan Ramón Rey Blas, Juan Sanchis, Nicolás Manuel Maneiro-Melón, Ana Pardo Sanz, Joan Antoni Gómez-Hospital, Luisa Salido
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
ARDS
medicine.medical_specialty
Acute coronary syndrome
Myocardial Infarction
Comorbidity
030204 cardiovascular system & hematology
Logistic regression
Risk Assessment
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
Síndrome coronario agudo
Myocardial infarction
Hospital Mortality
Prospective Studies
Mortality
Pandemics
ARDS
acute respiratory distress syndrome
COVID-19
coronavirus disease 2019
Aged
Retrospective Studies
PCI
percutaneous coronary intervention
business.industry
SARS-CoV-2
NSTEMI
non-ST-segment elevation myocardial infarction
Outbreak
COVID-19
STEMI
ST-segment elevation myocardial infarction
General Medicine
Middle Aged
medicine.disease
AMI
acute myocardial infarction
Spain
Conventional PCI
Propensity score matching
Mortalidad
Original Article
Female
Infarto de miocardio
business
Cohort study
Follow-Up Studies
Zdroj: Revista Espanola De Cardiologia (English Ed.)
Revista Española de Cardiología (English Edition)
ISSN: 1885-5857
Popis: Introduction and objectives Despite advances in treatment, patients with acute myocardial infarction (AMI) still exhibit unfavorable short- and long-term prognoses. In addition, there is scant evidence about the clinical outcomes of patients with AMI and coronavirus disease 2019 (COVID-19). The objective of this study was to describe the clinical presentation, complications, and risk factors for mortality in patients admitted for AMI during the COVID-19 pandemic. Methods This prospective, multicenter, cohort study included all consecutive patients with AMI who underwent coronary angiography in a 30-day period corresponding chronologically with the COVID-19 outbreak (March 15 to April 15, 2020). Clinical presentations and outcomes were compared between COVID-19 and non-COVID-19 patients. The effect of COVID-19 on mortality was assessed by propensity score matching and with a multivariate logistic regression model. Results In total, 187 patients were admitted for AMI, 111 with ST-segment elevation AMI and 76 with non-ST-segment elevation AMI. Of these, 32 (17%) were diagnosed with COVID-19. GRACE score, Killip-Kimball classification, and several inflammatory markers were significantly higher in COVID-19-positive patients. Total and cardiovascular mortality were also significantly higher in COVID-19-positive patients (25% vs 3.8% [P 140 (OR, 23.45; 95%CI, 2.52–62.51; P = .005) and COVID-19 (OR, 6.61; 95%CI, 1.82-24.43; P = .02) were independent predictors of in-hospital death. Conclusions During this pandemic, a high GRACE score and COVID-19 were independent risk factors associated with higher in-hospital mortality.
Databáze: OpenAIRE
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