A far-red, photo- and bio-stable fluorescent marker selective to the endoplasmic reticulum and its application to tunicamycin-treated HeLa cells

Autor:	Chulhun Kang, Jong Seung Kim, Myungkoo Suh, Rajesh Kumar, Hye Ri Kim, Chang Hoe Kim, Jae Hong Lee, Amit Sharma, W. Kim
Rok vydání:	2016
Předmět:	0301 basic medicine Cell Survival Endoplasmic Reticulum 010402 general chemistry 01 natural sciences Fluorescence Catalysis HeLa Structure-Activity Relationship 03 medical and health sciences chemistry.chemical_compound Biomarkers Tumor Materials Chemistry Humans Structure–activity relationship Inducer Fluorescent Dyes Dose-Response Relationship Drug Molecular Structure biology Chemistry Tunicamycin Endoplasmic reticulum Metals and Alloys Far-red General Chemistry biology.organism_classification 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials 030104 developmental biology Biochemistry Ceramics and Composites Unfolded protein response Biophysics HeLa Cells
Zdroj:	Chemical Communications. 52:7134-7137
ISSN:	1364-548X 1359-7345
DOI:	10.1039/c6cc02330d
Popis:	Herein, we developed an ER selective fluorescent ERp that exhibited a sharp fluorescence emission in the far-red region and high photo- and bio-stability in biological milieu. Its emission is insensitive to pH change and localized in the ER of the cells. Furthermore, it successfully demonstrated that the ER membrane is rapidly reorganized in the perinuclear region by an ER stress inducer, tunicamycin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721ae76ea5e41d1f0faa3c0fa24c1982 https://doi.org/10.1039/c6cc02330d Zobrazit plný text záznamu