Nonthyroidal action of propylthiouracil in euthyroid, hypothyroid and hyperthyroid man
| Autor: | Eugene D. Furth, David V. Becker, Kathleen L. Rives |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Graves' disease Clinical Biochemistry Thyroid Function Tests Biochemistry Thyroid function tests Hyperthyroidism Thyroxine-Binding Proteins Endocrinology Antithyroid Agents Hypothyroidism Internal medicine Iodine Isotopes medicine Humans In patient Euthyroid Clinical Trials as Topic Perchlorates medicine.diagnostic_test business.industry Thyroid disease Biochemistry (medical) medicine.disease Control subjects Graves Disease Thyroxine Propylthiouracil Potassium Triiodothyronine Thyroid function business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 26(3) |
| ISSN: | 0021-972X |
| Popis: | The nonthyroidal action of 6-n-propylthiouracil (6-PTU) on the metabolism of 131I-labeled thyroxine was investigated in patients with and without thyroid disease. Nineteen studies were performed in 15 hospitalized patients. Thyroidal radioiodine uptake was blocked with potassium perchlorate. 131I-labeled T4 was injected iv and its rate of disappearance was established by repeated determinations of PB131I over 7.5 days on average. PTU was then administered and the studies were continued. Other parameters of thyroid function and metabolic status were also examined serially. The rate of T4 degradation decreased in all 5 patients with active thyrotoxicosis. One patient with euthyroid Graves' disease, studied twice, and 2 hypothyroid patients also had decreases in thyroxine disappearance rates. There were no effects on the other tudy patients. Three control subjects, 2 with thyrotoxicosis, were included to define the specificity of these findings. It is concluded that 6-PTU has a nonthyroidal action in man whi... |
| Databáze: | OpenAIRE |
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