| Popis: |
In this prospective, case-control genetic study, 120 consecutive neovascular age-related macular degeneration (AMD) cases and 78 controls were enrolled. Two SNPs (rs2071559 and rs1870377) ofVEGF-Areceptor-2 (VEGFR-2) gene were analyzed with the technique of Real-Time PCR to investigate a genetic link between AMD andVEGFR-2gene polymorphisms in Italian patients. The frequency of theVEGFR-2genotype rs2071559 AA was significantly lower (18.33%) in patients with AMD than in the control subjects (34.62%;P=0.0095, chi-square test;Pcorr=0.038;OR=0.42, 95% CI 0.22 to 0.82). In conclusion, although with the limitations of a small sample size and the few SNPs studied, this study demonstrates a lower frequency ofVEGFR-2rs2071559 AA genotype in an AMD patient population, suggesting future studies on the roleVEGFR-2SNPs. |
