Short-term developmental outcomes in neonates born to mothers with COVID-19 from Wuhan, China
| Autor: | Ling-Kong Zeng, Sicong Peng, Feifan Xiao, Jianbo Shao, Shiwen Xia, Huaping Zhu, Kai Yan, Tiantian Xiao, Lai-Shuan Wang, Shoo K. Lee, Wen-Hao Yuan, Wenhao Zhou |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics China Disease Grey matter White matter 03 medical and health sciences 0302 clinical medicine Neonate Pregnancy 030225 pediatrics Pediatric surgery medicine Humans Severe acute respiratory syndrome coronavirus 2 030212 general & internal medicine Pandemics medicine.diagnostic_test Coronavirus disease 2019 business.industry SARS-CoV-2 Follow-up Infant Newborn Gestational age Brain COVID-19 Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Infectious Disease Transmission Vertical medicine.anatomical_structure Dysplasia Pediatrics Perinatology and Child Health Female Original Article business |
| Zdroj: | World Journal of Pediatrics |
| ISSN: | 1867-0687 |
| Popis: | Background Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging disease. The consequences of SARS-CoV-2 exposure in infants remain unknown. Therefore, this study aims to investigate whether neonates born to mothers with COVID-19 have adverse brain development. Methods This multicenter observational study was conducted at two designated maternal and children’s hospitals in Hubei Province, mainland China from February 1, 2020 to May 15, 2020. Neonates born to mothers with COVID-19 were enrolled. Brain magnetic resonance imaging (MRI) findings, and volumes of grey and white matters, and physical growth parameters were observed at 44 weeks corrected gestational age. Results Of 72 neonates born to mothers with COVID-19, 8 (11%) were diagnosed with COVID-19, 8 (11%) were critically ill, and no deaths were reported. Among the eight neonates that underwent brain MRI at corrected gestational age of 44 weeks, five neonates were diagnosed with COVID-19. Among these five neonates, three presented abnormal MRI findings including abnormal signal in white matter and delayed myelination in newborn 2, delayed myelination and brain dysplasia in newborn 3, and abnormal signal in the bilateral periventricular in newborn 5. The other three neonates without COVID-19 presented no significantly changes of brain MRI findings and the volumes of grey matter and white matter compared to those of healthy newborns at the equivalent age (P > 0.05). Physical growth parameters for weight, length, and head circumference at gestational age of 44 weeks were all above the 3rd percentile for all neonates. Conclusions Some of the neonates born to mothers with COVID-19 had abnormal brain MRI findings but these neonates did not appear to have poor physical growth. These findings may provide the information on the follow-up schedule on the neonates exposed to SARS-CoV-2, but further study is required to evaluate the association between the abnormal MRI findings and the exposure to SARS-CoV-2. Supplementary Information The online version contains supplementary material available at 10.1007/s12519-021-00426-z. |
| Databáze: | OpenAIRE |
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